Condition
Gastric Adenocarcinoma clinical trials and research
As of November 12, 2026, Find a Trial lists 64 Gastric Adenocarcinoma clinical trials that are recruiting, at sites in 19 countries (most in China (24), United States (23), France (5)). 1 was first registered in the last 30 days. By phase: Phase 2 (26), Phase 1 (8), Phase 3 (5), Phase 1/2 (2). The most active sponsors are Cancer Institute and Hospital, Chinese Academy of Medical Sciences (3), Memorial Sloan Kettering Cancer Center (2), Astellas Pharma Inc (2). There are also 7 NIH-funded research projects on Gastric Adenocarcinoma, with $4.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 64Clinical trials
- 7NIH research projects
- 1New in 30 days
- 19Countries
Newest Gastric Adenocarcinoma clinical trials
All recruiting trials (64)
-
68Ga-YQ-CC05: a new probe for detecting tumors with CCK2R
This study tests a radioactive probe called 68Ga-YQ-CC05 to see if it can safely help find tumors in adults with certain cancers using PET-CT imaging.
-
Neoadjuvant immunotherapy plus Nab-P-SOX for locally advanced gastric/GEJ cancer
This phase 2, single-arm study tests a pre-surgery treatment that combines a PD-1/CTLA-4 bispecific antibody with nab-paclitaxel, oxaliplatin, and S-1 in adults with HER2-negative, locally advanced gastric or GEJ cancer.
-
Maintenance therapy in metastatic gastric cancer: a multicenter look from Colombia
This study reviews medical records of adults with metastatic gastric cancer in Colombia to see how patients fare after starting maintenance therapy following initial chemotherapy.
-
AI-powered tumor response assessment after preoperative treatment in stomach and gastroesophageal junction cancer
Researchers are testing whether an AI tool called DeepTRG can reliably measure how much cancer remains in tissue removed after preoperative therapy in stomach and GEJ cancer, without needing a human to correct the AI results.
-
Image-guided platform helps find sentinel lymph nodes in early gastric cancer
This study tests whether an image-guided platform with a deep learning model can find and retrieve sentinel lymph nodes better than standard palpation in people with early gastric cancer undergoing LECS-SNNS.
-
Breath test to help detect gastrointestinal cancers early
A breath test that looks for signals in exhaled air to see if someone with gut cancer symptoms might have oesophageal, stomach, pancreatic, liver, or colorectal cancer and need urgent testing.
-
Perioperative HLX10 (serplulimab) with SOX chemotherapy for PD-L1 positive gastric/GEJ cancer
This study tests whether adding HLX10 (serplulimab) to the SOX chemotherapy before and after surgery helps people with PD-L1 positive, locally advanced gastric or GEJ cancer compared to SOX alone.
-
A combination therapy with ASP2138 and standard chemotherapy plus pembrolizumab for advanced stomach and GEJ cancer
This study tests ASP2138 along with pembrolizumab and chemotherapy to see if it helps people with advanced, inoperable, or metastatic gastric or GEJ cancer that is HER2-negative and CLDN18.2-positive.
-
HIPEC-primed therapy with serplulimab plus SOX/XELOX for locally advanced gastric cancer
This study tests a HIPEC-priming approach followed by PD-1 blocker–based chemotherapy to see if it helps people with locally advanced gastric cancer who have not yet spread.
-
Personalized ultrafractionated radiation plus immunotherapy for unresectable stomach cancer
This study tests, in patients with unresectable locally advanced stomach cancer who have not progressed after initial therapy, whether adding PULSAR radiation to ongoing systemic treatment improves control of the tumor.
-
JS107 plus toripalimab and chemotherapy as first-line treatment for CLDN18.2-positive gastric cancer
This trial tests whether JS107 added to toripalimab and XELOX is better than a similar regimen with sintilimab for patients with untreated, CLDN18.2-positive, HER2-negative advanced gastric or GEJ adenocarcinoma.
-
Olanzapine added to chemotherapy for gastric cancer to help keep weight and appetite up
This study tests whether adding low-dose olanzapine to standard neoadjuvant chemotherapy helps patients with gastric cancer maintain weight and appetite during treatment.
-
DISP-10 for advanced colorectal, gastric, and esophageal cancers
This trial will test a one-time combination of an engineered adenovirus (DV-10) and BCMA-directed CAR T cells (ide-cel) in adults with advanced colorectal, gastric, or esophageal cancers.
-
BHB810 in advanced gastric and GEJ cancer (early-phase)
This study tests whether BHB810 can be safely given every two weeks to adults with advanced gastric or GEJ adenocarcinoma and looks at its effect, how the drug behaves in the body, and patient responses.
-
Gastric Precancerous Epithelial Pathway in India Using High-Definition Endoscopy
This study tests how common early gastric cancer is among adults 40 and older undergoing endoscopy in India.
-
Shr-1701 with or without Apatinib plus chemotherapy as neoadjuvant treatment for gastric cancer
This trial tests whether adding SHR-1701, with or without apatinib, to chemotherapy before surgery helps patients with resectable locally advanced gastric or gastroesophageal junction cancer.
-
AVA6103 for advanced or metastatic FAP-positive solid tumors
This study will test whether the experimental IV drug AVA6103 is safe and can help adults with advanced or metastatic FAP-positive cancers such as pancreatic, gastric/GEJ, cervical, or vulvar adenocarcinomas.
-
Adherence to a Remote Physical Activity Program on a Smartwatch and its Effect on Fatigue After Adjuvant Chemotherapy
This study tests whether sticking with an adapted physical activity program tracked on a smartwatch can reduce fatigue in adults who have finished adjuvant chemotherapy for certain cancers.
-
Zolbetuximab with chemotherapy for HER2-negative, Claudin 18.2–positive metastatic gastric or gastroesophageal junction adenocarcinoma
This project will try zolbetuximab together with FOLFOX or XELOX as first-line treatment for adults whose HER2-negative stomach or gastroesophageal junction cancers strongly express Claudin 18.2.
-
Fruquintinib with trastuzumab and XELOX for first-line treatment of HER2‑positive advanced stomach or GEJ cancer
This trial will try fruquintinib together with trastuzumab and XELOX to see if it helps people with HER2‑positive advanced stomach or gastroesophageal junction cancer as their first treatment.
-
PLX-61639 for advanced SMARCA4-deficient solid tumors
This trial will test a daily oral drug called PLX-61639 in people with advanced or metastatic solid tumors that have a SMARCA4 loss and who have no other approved treatment options.
-
Planned surgery or focused local treatment after chemo for metastatic upper-GI adenocarcinoma with undetectable ctDNA
This test sees if adding planned surgery or local treatments after three months of chemotherapy helps people with metastatic upper-gastrointestinal adenocarcinomas who have undetectable ctDNA.
-
IDE892 alone and with IDE397 for MTAP-deleted advanced solid tumors
This trial tests IDE892 by itself and combined with IDE397 in adults whose advanced solid tumors have MTAP deletion and have progressed after standard treatments.
-
Sintilimab added to SOX chemotherapy after surgery for PD-L1–positive pN3 gastric cancer
This trial will test whether adding the PD-1 blocker sintilimab to standard SOX chemotherapy after surgery helps people with PD-L1–positive, pathologic N3 gastric cancer stay cancer-free longer.
-
NRM-823 for advanced or metastatic refractory solid tumors
This trial tests whether NRM-823 is safe and can help people with advanced or metastatic head and neck, esophageal, gastric, or related cancers.
-
Cytoreductive surgery plus heated intraperitoneal chemotherapy for gastric cancer with peritoneal-only spread
This study will try cytoreductive surgery combined with heated intraperitoneal chemotherapy, together with preoperative chemotherapy and laparoscopic HIPEC, in adults whose gastric adenocarcinoma is limited to the peritoneum or shows positive peritoneal cytology.
-
BL-M07D1 versus chemotherapy for HER2-positive advanced gastric or gastroesophageal junction cancer
This trial tests whether BL-M07D1 works better than a doctor's choice of chemotherapy for adults with HER2‑positive locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma after first‑line anti‑HER2 therapy has failed.
-
Randomized Phase III treatment for CLDN18.2-positive unresectable locally advanced or metastatic gastric cancer
This trial will try IMC002 CAR T-cell therapy versus the doctor's choice of treatment for adults with CLDN18.2-positive unresectable locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma who have had at least two prior treatments.
-
Tislelizumab plus FLOT given before surgery for operable esophagus or stomach adenocarcinoma
This trial tests whether adding the immunotherapy drug tislelizumab to FLOT chemotherapy given before surgery helps people with locally advanced, resectable esophagus or stomach adenocarcinoma shrink tumors and better tolerate treatment.
-
MRD-guided postoperative treatment for locally advanced gastric cancer
This trial will test whether using MRD results from peritoneal lavage fluid to decide on adding intraperitoneal chemotherapy after surgery can lower peritoneal relapse in people with locally advanced gastric cancer.
-
Enhanced recovery after laparoscopic distal gastrectomy without routine abdominal drainage tubes
This trial will test whether skipping routine abdominal drainage tubes during enhanced recovery after laparoscopic distal gastrectomy helps adults (18–80) with gastric adenocarcinoma recover as well as using drains.
-
Conversion therapy with surgery and targeted para‑aortic radiotherapy for gastric cancer with retroperitoneal (station 16) lymph node spread
This trial tests whether chemotherapy (SOX with or without a PD‑1 inhibitor), followed by D2 gastrectomy and para‑aortic radiotherapy, helps people with gastric adenocarcinoma who have only para‑aortic lymph node metastases live longer without their cancer progressing compared with standard chemotherapy alone.
-
Adding paclitaxel into the abdominal cavity for gastric cancer that has spread to the peritoneum
This trial will try adding paclitaxel delivered directly into the abdomen to standard IV chemotherapy for people with gastric or gastroesophageal junction cancer that has spread to the lining of the abdominal cavity to see if it slows disease growth and helps them live longer.
-
Direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal and gastrointestinal tumors
This trial will try a single direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal tumors to see if it is safe for adults with advanced metastatic gastrointestinal or peritoneal cancers who have not responded to standard treatments.
-
Best time for minimally invasive local treatment after first-line systemic therapy for limited (oligo) esophageal or stomach cancer
This trial will test whether giving local treatment (surgery or radiation) earlier or later after first-line systemic therapy works better for people whose esophageal or stomach cancer has spread to only a few sites.
-
Combining Adebrelimab with Chemoradiotherapy and Surgery for Gastric Cancer
This study is testing if adding a new immunotherapy drug called Adebrelimab to standard treatments for stomach cancer can help patients with advanced cases do better and have a better chance of recovery.
-
Gastric cancer screening using stool H. pylori high-risk gene testing and a risk questionnaire
We are testing whether a stool H. pylori genetic risk test plus a short risk questionnaire can find gastric cancer earlier in adults aged 40 and older.
-
Robotic surgery for advanced gastric cancer
This study is testing if robotic surgery can safely help people with advanced stomach cancer by reducing blood loss and hospital stays compared to traditional methods.
-
Combination treatment for advanced gastric and gastro-esophageal junction cancer
This study is testing a new combination treatment for people with advanced stomach cancer to see if it helps them before and after surgery.
-
Combining Sintilimab with Chemotherapy for Stage III Gastric Cancer Treatment
This study is testing if combining a new drug called Sintilimab with chemotherapy can help people with stage III gastric cancer feel better after their surgery.
-
Assessing lymph node removal quality during minimally invasive gastric cancer surgery
This study is testing a new scoring system to see if it can help doctors better assess lymph node removal during minimally invasive surgery for stomach cancer and improve patient outcomes.
-
Reducing dosing frequency of immune checkpoint inhibitors in advanced cancers
This study is testing if giving immune checkpoint inhibitors less often can still help people with advanced cancers feel better while making treatment easier and cheaper.
-
Collecting health information to understand and prevent gastric cancer
This study is trying to gather health information from people with early signs of gastric cancer, as well as healthy individuals and those already diagnosed, to better understand what might lead to this type of cancer.
-
Combination of OBP-301 and Pembrolizumab for Advanced Esophagogastric Cancer
This study is trying a new treatment combining OBP-301 and pembrolizumab to see if it can help people with advanced esophageal and gastric cancer who haven't responded well to previous immunotherapy.
-
Dostarlimab treatment for advanced or metastatic cancers with specific genetic markers
This study is testing if the immunotherapy dostarlimab can help people with certain advanced cancers that have specific genetic markers feel better compared to standard chemotherapy.
-
Assessing biomarkers after surgery for oesophagogastric cancer
This study is trying to find out if certain biological markers in patients who had surgery for oesophageal and gastric cancer can help predict how well they will respond to treatment and their chances of recovery.
-
Combination treatment for advanced gastric and gastroesophageal junction cancer
This study is testing a new combination of two medications with chemotherapy to see if it can help adults with advanced stomach or gastroesophageal junction cancer.
-
Combining pembrolizumab, trastuzumab, and chemotherapy for HER2+ esophagogastric cancer
This study is testing if adding pembrolizumab and trastuzumab to standard chemotherapy can help people with resectable HER2+ esophagogastric cancer do better in their treatment.
-
Using dostarlimab to avoid surgery in localized gastric cancer
This study is testing if the drug dostarlimab can help patients with certain types of stomach cancer avoid surgery by seeing if their cancer completely responds to treatment.
-
Combining TRK-950 with Ramucirumab and Paclitaxel for Gastric Cancer
This study is testing if adding a new drug called TRK-950 to the standard treatments ramucirumab and paclitaxel can help people with gastric cancer live longer and feel better.
-
Total neoadjuvant chemotherapy for advanced gastric and gastroesophageal cancer
This study is testing two different chemotherapy plans for people with advanced stomach cancer to see which one helps them better tolerate treatment and successfully have surgery.
-
Using paclitaxel and surgery to improve outcomes in gastric cancer patients
This study is testing if giving a chemotherapy drug called paclitaxel along with surgery can help people with advanced gastric cancer live longer and feel better.
-
Long-term outcomes of endoscopic procedures for upper gastrointestinal cancers
This study looks at how well certain endoscopic procedures work for treating larger upper gastrointestinal cancers and what the long-term results are for patients.
-
Robotic surgery and heated chemotherapy for gastric cancer with peritoneal spread
This study is testing if a new robotic surgery combined with heated chemotherapy can help people with advanced stomach cancer that has spread to the abdominal lining feel better and live longer.
-
Assessing nutritional status in gastric cancer patients using bioelectrical impedance analysis
This study is testing if a special method can help doctors check the nutrition and body health of gastric cancer patients during their treatment to better support their care.
-
Testing ASP2138 for stomach and pancreatic cancer treatment
This study is testing a new drug called ASP2138 to see if it can help adults with stomach or pancreatic cancer by boosting their immune response when used alone or with standard treatments.
-
Combining chemotherapy and immunotherapy for advanced esophagogastric cancer
This study is testing a new treatment plan that combines two chemotherapy drugs with an immunotherapy to see if it helps people with advanced esophagogastric cancer feel better and live longer.
-
Observing cancer recurrence using a blood test
This study is testing a new blood test to see if it can help find out if cancer comes back in people who have been treated for early-stage solid tumors.
-
Evaluating the impact of tumor microenvironment on treatment outcomes in advanced gastric cancer
This study is trying to see how the environment around tumors in patients with advanced stomach cancer affects how well their treatment works.
-
Registry for gastric and esophageal cancer treatments in Germany
This study is collecting information on how patients in Germany with advanced esophageal and stomach cancers are treated to see how well different treatments work in real life.
-
Combination of chemotherapy and immunotherapy for advanced esophageal and gastric cancer
This study is testing a new combination of chemotherapy and immunotherapy to see if it helps people with advanced esophageal and gastric cancer feel better and have fewer side effects than current treatments.
-
Combining Anti-PD-1 Therapy with Metformin and Rosiglitazone for Cancer Treatment
This study is testing if combining a cancer treatment called anti-PD-1 therapy with two diabetes medications, Metformin and Rosiglitazone, can help people with advanced solid tumors fight their cancer better.
-
Combining Paclitaxel, Oxaliplatin, and S-1 for treating advanced gastric cancer
This study is testing a new combination of three drugs to see if it can help people with advanced stomach cancer become healthy enough for surgery.
-
Chemotherapy with or without radiation or surgery for oligometastatic esophageal or gastric cancer
This study is testing if adding radiation or surgery to chemotherapy helps people with oligometastatic esophageal or gastric cancer live longer and feel better.
NIH-funded research (7)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
-
Understanding how CDH1 loss drives aggressive stomach cancer and how to target it
Researchers are studying why certain advanced stomach cancers grow and spread, with a focus on CDH1 inactivation and related pathways to find ways to improve treatment for patients.
-
Common stem cell origin in Barrett's-related cancers
This research looks at whether a single stem cell type drives both esophageal and gastric cancers that arise from Barrett’s esophagus, with the aim of finding shared clues to prevent or treat these diseases.
-
Shared stem cell source for lower esophagus and upper stomach cancers
This project looks at whether the same type of stem cell drives cancers that start in Barrett's esophagus and the nearby stomach, with implications for people who have Barrett's esophagus or gastric intestinal metaplasia.
-
Targeting YAP1 to stop stomach cancer spread and immune suppression
This project looks for ways to block a protein called YAP1 to help people with advanced stomach (gastric) cancer that has spread to the lining of the abdomen.
-
Understanding how certain genetic changes lead to advanced stomach cancer
This study is looking into how a specific gene called CDH1 affects the growth of advanced stomach cancer, with the hope of finding better treatment options tailored to different types of the disease, so that patients can receive care that works best for them.
-
Understanding and targeting cancer stemness and immune suppression in advanced gastric cancer
This study is looking at how a protein called YAP1 affects advanced stomach cancer, especially in patients with cancer that has spread to the lining of the abdomen, to find new ways to treat this tough condition and help improve outcomes for patients.
-
Investigating the common origin of esophageal and gastric cancers
This study is looking into how esophageal adenocarcinoma and intestinal gastric cancer start and develop, aiming to find early warning signs and better treatments for people dealing with these cancers.
Related topics
Quick answers
How many Gastric Adenocarcinoma clinical trials are recruiting right now?
64, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 19 countries. The most sites are in China (24 trials), United States (23 trials), France (5 trials), Italy (5 trials), Japan (4 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 26, Phase 1: 8, Phase 3: 5, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.