Condition

Gastroesophageal Junction (GEJ) Adenocarcinoma clinical trials and research

• 6Clinical trials
• 8Countries

Newest Gastroesophageal Junction (GEJ) Adenocarcinoma clinical trials

All recruiting trials (6)

• Perioperative HLX10 (serplulimab) with SOX chemotherapy for PD-L1 positive gastric/GEJ cancer

  This study tests whether adding HLX10 (serplulimab) to the SOX chemotherapy before and after surgery helps people with PD-L1 positive, locally advanced gastric or GEJ cancer compared to SOX alone.

  Recruiting at 5 sites Phase 2 National Cancer Center, Japan · Chiba, Chiba and 17 other locations · NCT07699939

• A combination therapy with ASP2138 and standard chemotherapy plus pembrolizumab for advanced stomach and GEJ cancer

  This study tests ASP2138 along with pembrolizumab and chemotherapy to see if it helps people with advanced, inoperable, or metastatic gastric or GEJ cancer that is HER2-negative and CLDN18.2-positive.

  Recruiting at 12 sites Phase 3 Astellas Pharma Inc · Saint Louis Park, Minnesota and 11 other locations · NCT07673887

• BHB810 in advanced gastric and GEJ cancer (early-phase)

  This study tests whether BHB810 can be safely given every two weeks to adults with advanced gastric or GEJ adenocarcinoma and looks at its effect, how the drug behaves in the body, and patient responses.

  Recruiting at 2 sites Phase 1/2 BigHat Biosciences, Inc. · Duarte, California and 2 other locations · NCT07529808

• PLX-61639 for advanced SMARCA4-deficient solid tumors

  This trial will test a daily oral drug called PLX-61639 in people with advanced or metastatic solid tumors that have a SMARCA4 loss and who have no other approved treatment options.

  Recruiting at 10 sites Phase 1 Plexium, Inc. · Scottsdale, Arizona and 9 other locations · NCT07284186

• Neoadjuvant pembrolizumab with FLOT chemotherapy and short-course radiation for locally advanced gastroesophageal junction cancer

  This treatment plan will test whether pembrolizumab plus FLOT chemotherapy given before and after a short course of radiation can let some patients with locally advanced gastroesophageal junction adenocarcinoma avoid surgery or improve cancer control.

  Recruiting Phase 2 National Cancer Center Hospital East · Kashiwa, Chiba · NCT07018570

• Testing ASP2138 for stomach and pancreatic cancer treatment

  This study is testing a new drug called ASP2138 to see if it can help adults with stomach or pancreatic cancer by boosting their immune response when used alone or with standard treatments.

  Recruiting at 42 sites Phase 1 Astellas Pharma Inc · Orange, California and 45 other locations · NCT05365581

Related topics

Quick answers

How many Gastroesophageal Junction (GEJ) Adenocarcinoma clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (4 trials), Japan (4 trials), South Korea (2 trials), China (2 trials), Puerto Rico (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 2, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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