Condition

Gastroesophageal Adenocarcinoma clinical trials and research

• 15Clinical trials
• 20Countries

Newest Gastroesophageal Adenocarcinoma clinical trials

All recruiting trials (15)

• First-in-human test of HH160 in people with advanced solid tumors

  HH160 is being tested to see if it is safe and how it behaves in the body, to see if it has early signs of helping various advanced cancers in adults.

  Recruiting at 3 sites Phase 1 Huahui Health · Waratah, New South Wales and 2 other locations · NCT07623369

• DISP-10 for advanced colorectal, gastric, and esophageal cancers

  This trial will test a one-time combination of an engineered adenovirus (DV-10) and BCMA-directed CAR T cells (ide-cel) in adults with advanced colorectal, gastric, or esophageal cancers.

  Recruiting at 6 sites Phase 1 Dispatch Biotherapeutics · Duarte, California and 6 other locations · NCT07544589

• BHB810 in advanced gastric and GEJ cancer (early-phase)

  This study tests whether BHB810 can be safely given every two weeks to adults with advanced gastric or GEJ adenocarcinoma and looks at its effect, how the drug behaves in the body, and patient responses.

  Recruiting at 2 sites Phase 1/2 BigHat Biosciences, Inc. · Duarte, California and 2 other locations · NCT07529808

• Personalized biomarker-guided therapy to preserve organs in gastroesophageal cancer

  This trial tests a biomarker-driven treatment approach that combines chemotherapy, an immune therapy, and targeted drugs to see if some patients can avoid surgery.

  Recruiting at 4 sites Phase 2 American Association for Cancer Research · Los Angeles, California and 3 other locations · NCT07290985

• Planned surgery or focused local treatment after chemo for metastatic upper-GI adenocarcinoma with undetectable ctDNA

  This test sees if adding planned surgery or local treatments after three months of chemotherapy helps people with metastatic upper-gastrointestinal adenocarcinomas who have undetectable ctDNA.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07282912

• Zanidatamab with pembrolizumab and chemotherapy for HER2- and PD-L1-positive metastatic gastroesophageal adenocarcinoma

  This trial tests whether adding zanidatamab to pembrolizumab plus chemotherapy helps people with untreated HER2- and PD-L1-positive metastatic gastroesophageal adenocarcinoma.

  Recruiting at 14 sites Phase 2 Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest · Berlin and 19 other locations · NCT07176312

• Novel perioperative drug combinations for locally advanced resectable gastric and gastroesophageal junction adenocarcinoma

  This trial will test new drugs or drug combinations given before and around surgery for people with locally advanced, resectable stomach or gastroesophageal junction adenocarcinoma who haven't had prior treatment.

  Recruiting at 54 sites Phase 2 AstraZeneca · Newark, Delaware and 69 other locations · NCT07069712

• Combining Adebrelimab with Chemoradiotherapy and Surgery for Gastric Cancer

  This study is testing if adding a new immunotherapy drug called Adebrelimab to standard treatments for stomach cancer can help patients with advanced cases do better and have a better chance of recovery.

  Recruiting Phase 2 Jiangsu Cancer Institute & Hospital · Nanjing, Province · NCT06985602

• Testing BDC-4182 for advanced gastric and gastroesophageal cancer

  This study is testing a new drug called BDC-4182 to see if it's safe and how well it works for people with advanced gastric and gastroesophageal cancer.

  Recruiting at 16 sites Phase 1/2 Bolt Biotherapeutics, Inc. · Darlinghurst, New South Wales and 15 other locations · NCT06921837

• TQB2102 with immune therapy, with or without chemotherapy, for HER2‑positive advanced gastroesophageal cancer

  This test will see if TQB2102, a new HER2‑targeting antibody‑drug conjugate given with benmelstobart and sometimes the PD‑1 antibody penpulimab and chemotherapy, can improve responses in people with unresectable, recurrent, or metastatic HER2‑positive gastroesophageal adenocarcinoma.

  Recruiting Phase 2 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Fuyang, Anhui and 38 other locations · NCT06767800

• Personalized cancer vaccine for patients with muscle-invasive bladder cancer

  This study is testing a personalized cancer vaccine to see if it can help patients with muscle-invasive bladder cancer fight their disease by boosting their immune response.

  Recruiting Phase 1 Washington University School of Medicine · Orlando, Florida and 2 other locations · NCT06529822

• Combination treatment for advanced esophageal cancer

  This study is testing a new combination of treatments for patients with advanced esophageal cancer to see if it is safe and effective for those who haven't had treatment before.

  Recruiting at 46 sites Phase 1/2 Merck Sharp & Dohme LLC · Tucson, Arizona and 49 other locations · NCT06469944

• Combination therapies for advanced gastroesophageal cancer

  This study is testing two different treatment combinations for people with advanced stomach cancer to see which one works better after their first treatment didn't help.

  Recruiting at 44 sites Phase 1/2 Merck Sharp & Dohme LLC · Tucson, Arizona and 45 other locations · NCT06445972

• Combining zanidatamab with standard treatment for advanced HER2 positive gastroesophageal cancer

  This study is testing if adding a new drug called zanidatamab to standard treatments can help people with advanced HER2 positive gastroesophageal cancer live longer without their cancer getting worse.

  Recruiting at 18 sites Phase 2 Canadian Cancer Trials Group · Calgary, Alberta and 17 other locations · NCT06043427

• Response-adapted neoadjuvant therapy for gastroesophageal adenocarcinoma

  It tests whether adjusting pre-surgery chemotherapy based on early treatment response helps adults with stage IB–III stomach or gastroesophageal junction adenocarcinoma.

  Recruiting Phase 1 University of California, Irvine · Orange, California · NCT05733689

Related topics

Quick answers

How many Gastroesophageal Adenocarcinoma clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (9 trials), China (6 trials), Taiwan (4 trials), South Korea (3 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1/2: 4, Phase 1: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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