Investigating the common origin of esophageal and gastric cancers
Common Stem Cell of Origin for Junctional and Gastric Adenocarcinoma
This study is looking into how esophageal adenocarcinoma and intestinal gastric cancer start and develop, aiming to find early warning signs and better treatments for people dealing with these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10925194 on NIH RePORTER |
What this research studies
This research focuses on understanding the shared origins and genetic characteristics of esophageal adenocarcinoma and intestinal gastric cancer. It aims to identify the earliest precancerous lesions, such as Barrett's esophagus and gastric intestinal metaplasia, and how they progress to invasive disease. The research employs a collaborative approach involving oncologists, stem cell biologists, and cancer modeling experts to explore the cellular origins and potential treatments for these cancers. By utilizing advanced technologies, the team seeks to improve detection and therapeutic strategies for patients affected by these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with Barrett's esophagus or gastric intestinal metaplasia, as well as those diagnosed with esophageal adenocarcinoma or intestinal gastric cancer.
Not a fit: Patients with other types of cancers unrelated to the esophagus or stomach may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved detection methods and treatment options for esophageal and gastric cancers.
How similar studies have performed: Previous research has shown promising results in understanding the genetic links between esophageal and gastric cancers, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- University of Houston — Houston, United States (Active)
Researchers
- Principal investigator: Mckeon, Frank D. — University of Houston
- Study coordinator: Mckeon, Frank D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.