Condition

Focal Epilepsy clinical trials and research

• 18Clinical trials
• 8NIH research projects
• 8Countries

Newest Focal Epilepsy clinical trials

All recruiting trials (18)

• High-density flexible microneuroelectrode mapping to guide epilepsy surgery

  This study tests whether using high-density flexible microelectrocorticography during surgery helps guide the resection of the epileptogenic zone in people with drug-resistant focal epilepsy.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07656857

• RAP-219 for adults with focal seizures

  This study tests whether RAP-219 can reduce how often focal seizures happen in adults with focal epilepsy, compared with a placebo.

  Recruiting at 14 sites Phase 3 Rapport Therapeutics Inc. · Huntsville, Alabama and 13 other locations · NCT07594119

• Spatial scene memory testing for people with temporal lobe epilepsy having surgery

  This project tests whether a virtual tour memory task combined with brain recordings can show how adults with temporal lobe epilepsy recognize and recall places.

  Recruiting at 2 sites University of California, Davis · Sacramento, California and 1 other locations · NCT07580183

• RAP-219 in adults with focal seizures

  This study tests whether RAP-219 can safely reduce the number of focal seizures in adults with focal epilepsy compared with placebo.

  Recruiting at 24 sites Phase 3 Rapport Therapeutics Inc. · Birmingham, Alabama and 23 other locations · NCT07563881

• Probenecid for cluster seizures during presurgical epilepsy monitoring

  This trial tests whether probenecid can help control clusters of seizures in people with focal epilepsy during presurgical video-EEG monitoring.

  Recruiting Phase 2 Fondation Ophtalmologique Adolphe de Rothschild · Paris and 1 other locations · NCT07318870

• Long-term daily CB03-154 treatment for focal epilepsy

  This extension will try once-daily CB03-154 (up to 20 mg) in people with focal epilepsy who completed the prior Phase 2 study to see if it is safe, tolerated, and helps control seizures over up to two years.

  Recruiting Phase 2 Shanghai Zhimeng Biopharma, Inc. · Melbourne, Victoria · NCT07238868

• Long-term RAP-219 treatment for adults with focal onset seizures

  This trial will try RAP-219, an investigational anti-seizure medication, in adults with refractory focal seizures to see if it is safe long-term and helps reduce seizures.

  Recruiting at 7 sites Phase 2 Rapport Therapeutics Inc. · Boise, Idaho and 6 other locations · NCT07219407

• Butylphthalide for thinking and memory problems in older adults with focal epilepsy

  This trial will test whether taking butylphthalide capsules for 48 weeks improves thinking and memory in people aged 60–85 who have focal epilepsy and mild-to-moderate cognitive impairment while they continue their usual seizure medicines.

  Recruiting Phase 4 First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT07193277

• Seizure forecasting with subscalp EEG and wearables to guide epilepsy treatment

  This trial will try using forecasts from a subscalp EEG device plus wearable data to help people with temporal-lobe focal epilepsy who have frequent disabling seizures predict and manage their seizures.

  Recruiting at 3 sites Early Phase 1 Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT07012148

• CB03-154 for adults with focal epilepsy

  A drug called CB03-154 is being tested in adults with focal epilepsy to see if it can reduce seizures and if it is safe and tolerable, compared with placebo.

  Recruiting Phase 2 Shanghai Zhimeng Biopharma, Inc. · Melbourne, Victoria · NCT06612775

• Thalamic recordings during SEEG in children with focal epilepsy

  This will test whether adding small electrodes into specific thalamic areas during SEEG in children with focal epilepsy can identify thalamic seizure signals to help guide future targeted treatments.

  Recruiting Great Ormond Street Hospital for Children NHS Foundation Trust · London · NCT06453759

• Evaluating cognitive impairment in patients with focal cryptogenic epilepsy

  This study is testing how epilepsy affects thinking skills in people with different types of epilepsy to see if brain activity patterns can help understand their cognitive challenges better.

  Recruiting IRCCS San Raffaele · Milan · NCT06210022

• Evaluation of new flexible high-density electrodes for epilepsy surgery

  This study is testing new flexible electrode grids during epilepsy surgery to see if they can help improve the accuracy of the procedure for patients with lesional epilepsy.

  Recruiting Neurosoft Bioelectronics SA · Utrecht · NCT06205160

• Breathing techniques to prevent seizure-related breathing failure

  This study is testing breathing techniques to see if they can help people with hard-to-treat epilepsy breathe better during seizures.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05981755

• Investigating sleep and cognition in patients with focal epilepsy

  This study is testing how sleep patterns affect thinking skills in people with focal epilepsy to see if new treatments can help improve both sleep and cognition.

  Recruiting University of California, Davis · Sacramento, California · NCT05794295

• Using electrical stimulation on the scalp to treat epilepsy

  This study is testing if a type of electrical stimulation on the scalp can help people with different kinds of epilepsy have fewer and less severe seizures.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05673915

• Investigating brain activity in epilepsy patients using implanted electrodes

  This study is testing how brain activity in patients with hard-to-treat epilepsy can help us understand their seizures and how it affects their thinking and sleep.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT04653012

• Creating a brain atlas of cognition using SEEG recordings

  This study is trying to create a detailed map of how different parts of the brain are involved in thinking and memory by using special recordings from patients with epilepsy who are getting ready for surgery.

  Recruiting at 4 sites University Hospital, Grenoble · Grenoble and 3 other locations · NCT03644732

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Predicting seizure patterns in focal epilepsy patients

  Aims to create personalized models to forecast how often seizures will happen over time in people with focal epilepsy.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11402547

• Patchy (mosaic) genetic changes in focal epilepsy

  This project looks for mosaic (patchy) genetic mutations in brain tissue from people with mesial temporal lobe epilepsy to better understand causes and help guide future treatment choices.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11238895

• Predicting seizure patterns for people with focal epilepsy

  This project builds tools to forecast how often seizures may happen over time for people with focal epilepsy using long-term seizure records.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11169981

• Improving electrode placement for epilepsy treatment using brain imaging techniques

  This study is looking for ways to improve epilepsy treatment by using advanced imaging techniques to help doctors place electrodes more accurately in the brain, so they can better predict and manage seizures for patients who are having trouble with their epilepsy.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11042770

• Understanding genetic changes in difficult-to-treat focal epilepsy

  This study is looking at the genetic differences in the brains of people with focal epilepsy who haven't found relief from regular treatments, hoping to uncover new ways to help them feel better.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11001691

• Understanding and predicting seizures in patients with focal epilepsy

  This study is working on new ways to predict how often people with focal epilepsy might have seizures, using information from 450 patients to better understand their unique seizure patterns over time.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10931756

• Understanding genetic mutations in difficult-to-treat focal epilepsy

  This study is looking at the genetic causes of hard-to-treat epilepsy in people whose brain scans look normal, hoping to find hidden changes in their brain tissue that might explain their seizures and help improve their treatment options.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10892800

• Identifying brain connectivity markers to predict treatment response in focal epilepsy

  This study is looking at how the connections in your brain might help doctors predict how well you'll respond to epilepsy treatments, like medications or surgery, so they can find the best option for you.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10794219

Related topics

Quick answers

How many Focal Epilepsy clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (8 trials), Australia (4 trials), France (3 trials), China (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 2, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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