Understanding genetic changes in difficult-to-treat focal epilepsy
Discovery and functional characterization of somatic variation in intractable focal epilepsy
This study is looking at the genetic differences in the brains of people with focal epilepsy who haven't found relief from regular treatments, hoping to uncover new ways to help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11001691 on NIH RePORTER |
What this research studies
This research investigates the genetic variations that occur in the brains of patients with focal epilepsy, particularly those who do not respond to standard treatments. By examining tissue samples from patients who have undergone surgery for epilepsy, the study aims to identify specific genetic changes that contribute to the condition. The researchers will focus on understanding how these variations develop during brain formation and their role in causing seizures. This work is crucial for discovering new therapeutic options for patients suffering from this challenging form of epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with focal epilepsy, especially those who have not responded to anti-epileptic medications and may require surgical intervention.
Not a fit: Patients with focal epilepsy that is well-controlled with medication or those without a need for surgical evaluation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with refractory focal epilepsy, improving their quality of life.
How similar studies have performed: Previous research has shown promise in identifying genetic factors in epilepsy, suggesting that this approach could yield valuable insights and advancements.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Berglind, Ana Ericka — Univ of North Carolina Chapel Hill
- Study coordinator: Berglind, Ana Ericka
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.