Thalamic recordings during SEEG in children with focal epilepsy
Thalamic Recordings in Children Undergoing SEEG
This will test whether adding small electrodes into specific thalamic areas during SEEG in children with focal epilepsy can identify thalamic seizure signals to help guide future targeted treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 2 Years to 20 Years |
| Sex | All |
| Sponsor | Great Ormond Street Hospital for Children NHS Foundation Trust Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT06453759 on ClinicalTrials.gov |
What this trial studies
SEEG is used as part of the pre-surgical evaluation to locate where seizures start, but fewer than 35% of children become seizure free after current pathways of care. This project adds recording electrodes into the bilateral anterior, centromedian and pulvinar thalamic nuclei during clinically indicated SEEG at Great Ormond Street Hospital to capture ictal and interictal thalamic activity and measure functional connectivity. The recordings are intended to map thalamic signatures of seizure involvement and to build evidence for choosing personalised thalamic targets for neuromodulation such as DBS or RNS. Participation requires informed consent and the recordings are performed alongside the child’s planned clinical SEEG procedure.
Who should consider this trial
Good fit: Children undergoing SEEG as part of their pre-surgical evaluation at Great Ormond Street Hospital whose parents or guardians provide informed consent are eligible.
Not a fit: Children who are not candidates for SEEG, who do not have thalamic involvement in their seizures, or who do not proceed to neuromodulation may not directly benefit from the recordings.
Why it matters
Potential benefit: If successful, this could help clinicians pick better thalamic targets for stimulation and potentially improve seizure outcomes for some children.
How similar studies have performed: Thalamic DBS and RNS have shown promise in some adult and mixed-age reports, but systematic thalamic recordings in children are limited, so this approach is relatively novel for the pediatric population.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. All children undergoing SEEG as part of their pre-surgical evaluation at GOSH 2. Participants/parents/legal guardian provide informed consent for inclusion Exclusion Criteria: 1\) Lack of informed consent
Where this trial is running
London
- Great Ormond Street Hospital for Children — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Aswin Chari, PhD
- Email: aswin.chari.18@ucl.ac.uk
- Phone: 07726780817
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.