Thalamic recordings during SEEG in children with focal epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

SEEG is used as part of the pre-surgical evaluation to locate where seizures start, but fewer than 35% of children become seizure free after current pathways of care. This project adds recording electrodes into the bilateral anterior, centromedian and pulvinar thalamic nuclei during clinically indicated SEEG at Great Ormond Street Hospital to capture ictal and interictal thalamic activity and measure functional connectivity. The recordings are intended to map thalamic signatures of seizure involvement and to build evidence for choosing personalised thalamic targets for neuromodulation such as DBS or RNS. Participation requires informed consent and the recordings are performed alongside the child’s planned clinical SEEG procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. All children undergoing SEEG as part of their pre-surgical evaluation at GOSH
2. Participants/parents/legal guardian provide informed consent for inclusion

Exclusion Criteria:

1\) Lack of informed consent

Where it's running

• Great Ormond Street Hospital for Children
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Aswin Chari, PhD
• Email: aswin.chari.18@ucl.ac.uk
• Phone: 07726780817

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.