Condition

Refractory Epilepsy clinical trials and research

• 8Clinical trials
• 1New in 30 days
• 5Countries

Newest Refractory Epilepsy clinical trials

All recruiting trials (8)

• Biomarker study to predict Vagus Nerve Stimulation response in adults with refractory epilepsy

  This study tests whether biomarkers and network measures can predict how adults with refractory epilepsy will respond to vagus nerve stimulation (VNS) after implantation.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels · NCT07909486

• Cannabidiol as add-on therapy for children with refractory epilepsy (CBD-uN1que): an individualized N-of-1 series

  This trial tests whether CBD oil helps reduce seizures in children with hard-to-treat epilepsy, using a series of personalized N-of-1 comparisons against a placebo.

  Recruiting Phase 3 UMC Utrecht · Utrecht, Utrecht · NCT07668856

• Real-world use of the OneRF Ablation System for epilepsy

  This registry collects real-world outcomes and device performance from patients with drug-resistant epilepsy who are treated with SEEG-guided RF ablation using the OneRF system.

  Recruiting at 3 sites NeuroOne Medical Technologies Corporation · Miami, Florida and 2 other locations · NCT07546253

• Investigating white matter fibers in the brain during wakefulness and sleep

  This study is testing how sleep affects the connections in the brain's white matter for people aged 14-65 with drug-resistant epilepsy to help improve treatment options.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06524479

• One-of-a-kind self‑administered web music therapy for epilepsy

  This test sees if daily listening to specific music through a web app can reduce epileptic brain activity in adults with medication‑resistant focal epilepsy who have an RNS implant.

  Recruiting Dartmouth-Hitchcock Medical Center · Worcester, Massachusetts and 1 other locations · NCT06425029

• Exploring the effects of blue light on vagus nerve stimulation for epilepsy treatment

  This study is testing if blue light can make vagus nerve stimulation work better for people with epilepsy who still have seizures despite treatment.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Woluwe-Saint-Lambert · NCT06304389

• Optimizing brain stimulation for epilepsy treatment

  This study is testing if adjusting the settings of brain stimulation devices can help people with hard-to-treat epilepsy have fewer seizures.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05493722

• Creating a brain atlas of cognition using SEEG recordings

  This study is trying to create a detailed map of how different parts of the brain are involved in thinking and memory by using special recordings from patients with epilepsy who are getting ready for surgery.

  Recruiting at 4 sites University Hospital, Grenoble · Grenoble and 3 other locations · NCT03644732

Related topics

Quick answers

How many Refractory Epilepsy clinical trials are recruiting right now?

8, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (3 trials), Belgium (2 trials), China (1 trial), Netherlands (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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