Using electrical stimulation on the scalp to treat epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates the effectiveness of transcranial direct current stimulation (tDCS) in reducing the frequency and severity of seizures in patients with focal epilepsy, generalized onset epilepsy, or sleep-related epileptic encephalopathy. The study aims to explore various treatment protocols, including the feasibility and safety of using tDCS at home. Participants will receive either low or high levels of electrical stimulation to assess its impact on seizure control over time.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Clinical diagnosis of generalized onset or focal epilepsy or sleep-related epileptic encephalopathy.
* Estimated to have at least 2 countable seizures per month or spike-wave index ≥50%.
* Has not had control with at least 2 anti-seizure medicines.
* Able to maintain a constant medication for duration of the study (rescue meds allowed).
* Subject or legally authorized representative is able to understand consent and keep a seizure diary in English.

Exclusion Criteria:

* A disease likely to progress over course of the study.
* Psychogenic non-epileptic seizures.
* Suicide attempt or psychiatric hospitalization past 2 years.
* A skin condition interfering with scalp electrodes or allergy to silver.
* Women will verify not pregnant, and if applicable, have a serum pregnancy test.
* Implanted devices (e.g. pacemakers)-except VNS, which is allowed.

Where it's running

• Mayo Clinic Minnesota
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Brian Lundstrom, MD, PhD — Mayo Clinic
• Study coordinator: Precylla Ruiz
• Email: ruiz.precylla@mayo.edu
• Phone: 507-538-6606

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.