Clinical trial Recruiting at 1 site Interventional Ages 18 to 40

Investigating sleep and cognition in patients with focal epilepsy

Official title: Sleep Architecture & Cognition in Focal Epilepsy

Run by University of California, Davis · NCT05794295 · Data updated 2026-11-12

This study is testing how sleep patterns affect thinking skills in people with focal epilepsy to see if new treatments can help improve both sleep and cognition.

More Focal Epilepsy trials

Quick facts

Study typeInterventional
Ages18 Years to 40 Years
SexAll
Enrollment40 (estimated)
SponsorUniversity of California, Davis
Academic / other
Locations1 site (Sacramento, California)
StatusRecruiting
StartedJanuary 24, 2025
Main results expectedDecember 1, 2026
Study endsJune 2028
Registry record updatedAugust 7, 2026
Trial IDNCT05794295 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18-40 with a diagnosis of focal epilepsy who can cooperate with study protocols.

Probably not a fit

Patients with significant neurological disorders affecting cognition or those currently using medications that impact cognitive function may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the relationship between sleep architecture and cognitive deficits in patients with focal epilepsy (FE) compared to healthy controls. Participants will wear an actigraph and a home sleep study device, followed by two nights of testing at California Sleep Solutions, where they will undergo EEG monitoring and cognitive assessments. The study aims to characterize sleep patterns in FE and evaluate the effects of acoustic and electrical stimulation on sleep and cognitive processing. The ultimate goal is to develop tailored interventions to improve sleep and cognition in individuals with epilepsy.

Why it matters

Potential benefit: If successful, this study could lead to improved cognitive functioning and sleep quality for patients with focal epilepsy.

How similar studies have gone: While the specific approach of this study is novel, previous studies have indicated potential benefits of sleep interventions in epilepsy management.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 - 40 years of age
* Focal Epilepsy
* Capacity to fully cooperate and follow directions
* no other significant neurological disorders which could affect cognition

Exclusion Criteria:

* Current use of any medications that can significantly affect cognition
* No severe sleep apnea

Where it's running

  • UC Davis
    Sacramento, California, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • High-density flexible microneuroelectrode mapping to guide epilepsy surgery

    This study tests whether using high-density flexible microelectrocorticography during surgery helps guide the resection of the epileptogenic zone in people with drug-resistant focal epilepsy.

    Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07656857

  • RAP-219 for adults with focal seizures

    This study tests whether RAP-219 can reduce how often focal seizures happen in adults with focal epilepsy, compared with a placebo.

    Recruiting at 14 sites Phase 3 Rapport Therapeutics Inc. · Huntsville, Alabama and 13 other locations · NCT07594119

  • Spatial scene memory testing for people with temporal lobe epilepsy having surgery

    This project tests whether a virtual tour memory task combined with brain recordings can show how adults with temporal lobe epilepsy recognize and recall places.

    Recruiting at 2 sites University of California, Davis · Sacramento, California and 1 other locations · NCT07580183

  • RAP-219 in adults with focal seizures

    This study tests whether RAP-219 can safely reduce the number of focal seizures in adults with focal epilepsy compared with placebo.

    Recruiting at 24 sites Phase 3 Rapport Therapeutics Inc. · Birmingham, Alabama and 23 other locations · NCT07563881

  • Probenecid for cluster seizures during presurgical epilepsy monitoring

    This trial tests whether probenecid can help control clusters of seizures in people with focal epilepsy during presurgical video-EEG monitoring.

    Recruiting Phase 2 Fondation Ophtalmologique Adolphe de Rothschild · Paris and 1 other locations · NCT07318870

  • Long-term daily CB03-154 treatment for focal epilepsy

    This extension will try once-daily CB03-154 (up to 20 mg) in people with focal epilepsy who completed the prior Phase 2 study to see if it is safe, tolerated, and helps control seizures over up to two years.

    Recruiting Phase 2 Shanghai Zhimeng Biopharma, Inc. · Melbourne, Victoria · NCT07238868

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.