Creating a brain atlas of cognition using SEEG recordings
Official title: Atlas of Human Cognition by SEEG
Run by University Hospital, Grenoble · NCT03644732 · Data updated 2026-11-12
This study is trying to create a detailed map of how different parts of the brain are involved in thinking and memory by using special recordings from patients with epilepsy who are getting ready for surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University Hospital, Grenoble Academic / other |
| Locations | 4 sites (Grenoble and 3 other locations) |
| Status | Recruiting |
| Started | April 5, 2018 |
| Main results expected | March 2028 |
| Study ends | September 2030 |
| Registry record updated | March 19, 2024 |
| Trial ID | NCT03644732 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with drug-resistant focal epilepsy who require SEEG exploration as part of their presurgical assessment.
✕Probably not a fit
Patients who are not undergoing SEEG exploration or those with conditions that prevent participation, such as legal protection measures or pregnancy, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The MAPCOG-SEEG project aims to compile a comprehensive database of brain recordings related to cognitive functions in patients undergoing pre-surgical assessment for refractory epilepsy. This observational study utilizes stereoelectroencephalography (SEEG) to accurately identify the epileptogenic zone while also mapping cognitive functions that are critical for daily life. By employing advanced techniques like Dynamic Spectral Imaging, the study seeks to enhance our understanding of complex cognitive tasks beyond traditional methods. The ultimate goal is to develop the first atlas of human cognition with high temporal and spatial resolution.
Why it matters
Potential benefit: If successful, this study could significantly improve surgical outcomes for patients with refractory epilepsy by providing detailed insights into cognitive functions.
How similar studies have gone: While the approach of using SEEG for cognitive mapping is innovative, similar studies have shown promise in enhancing our understanding of brain functions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Drug-resistant focal epilepsy * Justified SEEG exploration in the context of presurgical assessment of epilepsy * Written non-opposition to study participation * Intellectual capacities compatible with the compliance in the cognitive tasks Exclusion Criteria: * Major Patient undergoing a legal protection measure or patient deprived of liberty as a result of a judicial or administrative decision * Impossibility of collecting information on exposure (recent arrival in France, foreign language, etc.) * Pregnant women (Contraindication to SEEG exploration)
Where it's running
-
University Hospital, Grenoble
Grenoble, France Recruiting -
CHRU Nancy
Nancy, France Recruiting -
Hôpital Ste Anne
Paris, France Recruiting -
CHU Rennes
Rennes, France Recruiting
Study contacts
- Principal investigator: Philippe Kahane, MD/PhD — University Hospital, Grenoble
- Study coordinator: Philippe Kahane, MD/PhD
- Email: pkahane@chu-grenoble.fr
- Phone: +33 476 765 488
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Biomarker study to predict Vagus Nerve Stimulation response in adults with refractory epilepsy
This study tests whether biomarkers and network measures can predict how adults with refractory epilepsy will respond to vagus nerve stimulation (VNS) after implantation.
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Cannabidiol as add-on therapy for children with refractory epilepsy (CBD-uN1que): an individualized N-of-1 series
This trial tests whether CBD oil helps reduce seizures in children with hard-to-treat epilepsy, using a series of personalized N-of-1 comparisons against a placebo.
-
High-density flexible microneuroelectrode mapping to guide epilepsy surgery
This study tests whether using high-density flexible microelectrocorticography during surgery helps guide the resection of the epileptogenic zone in people with drug-resistant focal epilepsy.
-
RAP-219 for adults with focal seizures
This study tests whether RAP-219 can reduce how often focal seizures happen in adults with focal epilepsy, compared with a placebo.
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Spatial scene memory testing for people with temporal lobe epilepsy having surgery
This project tests whether a virtual tour memory task combined with brain recordings can show how adults with temporal lobe epilepsy recognize and recall places.
-
RAP-219 in adults with focal seizures
This study tests whether RAP-219 can safely reduce the number of focal seizures in adults with focal epilepsy compared with placebo.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.