Creating a brain atlas of cognition using SEEG recordings
Atlas of Human Cognition by SEEG
This study is trying to create a detailed map of how different parts of the brain are involved in thinking and memory by using special recordings from patients with epilepsy who are getting ready for surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University Hospital, Grenoble Academic / other |
| Locations | 4 sites (Grenoble and 3 other locations) |
| Trial ID | NCT03644732 on ClinicalTrials.gov |
What this trial studies
The MAPCOG-SEEG project aims to compile a comprehensive database of brain recordings related to cognitive functions in patients undergoing pre-surgical assessment for refractory epilepsy. This observational study utilizes stereoelectroencephalography (SEEG) to accurately identify the epileptogenic zone while also mapping cognitive functions that are critical for daily life. By employing advanced techniques like Dynamic Spectral Imaging, the study seeks to enhance our understanding of complex cognitive tasks beyond traditional methods. The ultimate goal is to develop the first atlas of human cognition with high temporal and spatial resolution.
Who should consider this trial
Good fit: Ideal candidates include individuals with drug-resistant focal epilepsy who require SEEG exploration as part of their presurgical assessment.
Not a fit: Patients who are not undergoing SEEG exploration or those with conditions that prevent participation, such as legal protection measures or pregnancy, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly improve surgical outcomes for patients with refractory epilepsy by providing detailed insights into cognitive functions.
How similar studies have performed: While the approach of using SEEG for cognitive mapping is innovative, similar studies have shown promise in enhancing our understanding of brain functions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Drug-resistant focal epilepsy * Justified SEEG exploration in the context of presurgical assessment of epilepsy * Written non-opposition to study participation * Intellectual capacities compatible with the compliance in the cognitive tasks Exclusion Criteria: * Major Patient undergoing a legal protection measure or patient deprived of liberty as a result of a judicial or administrative decision * Impossibility of collecting information on exposure (recent arrival in France, foreign language, etc.) * Pregnant women (Contraindication to SEEG exploration)
Where this trial is running
Grenoble and 3 other locations
- University Hospital, Grenoble — Grenoble, France (Recruiting)
- CHRU Nancy — Nancy, France (Recruiting)
- Hôpital Ste Anne — Paris, France (Recruiting)
- CHU Rennes — Rennes, France (Recruiting)
Study contacts
- Principal investigator: Philippe Kahane, MD/PhD — University Hospital, Grenoble
- Study coordinator: Philippe Kahane, MD/PhD
- Email: pkahane@chu-grenoble.fr
- Phone: +33 476 765 488
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.