Condition

Depressive Disorder, Major clinical trials and research

• 31Clinical trials
• 34Countries

Newest Depressive Disorder, Major clinical trials

All recruiting trials (31)

• Brenipatide added to standard care for adults with major depressive disorder

  This study tests whether brenipatide, given alongside standard care, can help delay the return of depressive symptoms in adults with major depressive disorder.

  Recruiting at 47 sites Phase 3 Eli Lilly and Company · Birmingham, Alabama and 169 other locations · NCT07775300

• Student Precarity and Psychiatry: How Financial Struggles Relate to Depression and Loneliness

  This observational study looks at whether financial hardship and social isolation are linked to depression, suicidal thoughts, and loneliness among French university students.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, IDF · NCT07618208

• Seltorexant (JNJ-42847922) as monotherapy for adults and older adults with major depressive disorder

  This trial will test whether seltorexant works better than a placebo to reduce depressive symptoms in adults and elderly people with major depressive disorder.

  Recruiting at 53 sites Phase 3 Janssen Research & Development, LLC · Bryant, Arkansas and 52 other locations · NCT07573176

• MOCHA: Inpatient Mental Health Care for High-Risk Pregnancy

  This study tests a collaborative mental health program for pregnant or recently postpartum patients hospitalized for medical problems to see if it can be delivered feasibly and acceptably.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07540585

• Brenipatide added to standard antidepressant treatment for adults with major depression

  This trial will see if adding brenipatide to your current antidepressant treatment can delay the return of major depressive symptoms in adults with major depressive disorder.

  Recruiting at 170 sites Phase 3 Eli Lilly and Company · Moorpark, California and 179 other locations · NCT07412756

• Esketamine plus standard care for adolescents with major depressive disorder and acute suicidal thoughts or behavior

  This will test whether adding intranasal esketamine to usual care helps hospitalized adolescents with major depressive disorder and acute suicidal thoughts or behavior feel better faster than a psychoactive placebo plus usual care.

  Recruiting at 49 sites Phase 3 Janssen Research & Development, LLC · Birmingham, Alabama and 48 other locations · NCT07227454

• Everyday movement and subjective energy (MASE Project)

  This project tests whether increasing everyday, non-exercise activity can boost feelings of energy and reduce depressive symptoms in people with major depressive disorder or recent remission.

  Recruiting University of Bern · Bern · NCT07059234

• Neurofeedback treatment for major depression with anhedonia

  This study is testing a new neurofeedback treatment called Prism to see if it can help people with major depression and a lack of pleasure feel better over 24 weeks.

  Recruiting at 3 sites GrayMatters Health Ltd. · Providence, Rhode Island and 2 other locations · NCT06982820

• Home-based bright light therapy for adolescents with major depressive disorder

  This trial will test whether home-based bright light therapy helps adolescents aged 13–17 with major depressive disorder improve mood and emotional and cognitive function.

  Recruiting at 3 sites Peking University Sixth Hospital · Beijing, Beijing Municipality and 2 other locations · NCT06913309

• Using Roflumilast with Antidepressants for Major Depression

  This study is testing if adding Roflumilast to the antidepressant Fluoxetine can help people with major depression who aren't getting better with their current treatment.

  Recruiting Phase 3 Tanta University · Tanta · NCT06860958

• Impact of Mediterranean Diet and Mindful Eating on Depression in Obese Individuals

  This study is testing if following a Mediterranean Diet and practicing Mindful Eating can help reduce depression in people who are obese and struggling with major depressive disorder.

  Recruiting University Hospital Tuebingen · Stuttgart · NCT06621394

• Testing seltorexant for treating major depression with insomnia symptoms

  This study is testing if adding a new medication called seltorexant can help adults and older people with major depression and insomnia feel better when their current antidepressants aren't enough.

  Recruiting at 67 sites Phase 3 Janssen Research & Development, LLC · Birmingham, Alabama and 204 other locations · NCT06559306

• Pilot test of the bWell‑D VR cognitive program for adults with major depression

  This pilot will test whether a VR cognitive assessment and an eight‑week VR cognitive training program (bWell‑D) are acceptable and doable for adults with major depressive disorder who report cognitive problems.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06546917

• Comparing two methods of brain stimulation for treating depression in adolescents

  This study is testing if a faster way of brain stimulation can help teenagers with hard-to-treat depression feel better compared to the standard method.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT06528938

• Testing a new drug for treatment-resistant depression

  This study is testing a new drug called HNK to see if it can help people with treatment-resistant depression feel better when other medications haven't worked.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06511908

• Effects of exercise on gut bacteria, mood, and cognition in depression

  This study is testing whether a 12-week exercise program can improve mood, thinking, and gut health in people with Major Depressive Disorder.

  Recruiting University College Cork · Cork, Cork County · NCT06398496

• Emotion regulation intervention for depression and healthy individuals

  This study is testing a smartphone program that helps people with mild to moderate depression and healthy individuals learn to manage their emotions better and see if it makes a difference in how they feel.

  Recruiting Heidelberg University · Heidelberg · NCT06311136

• Comparing two methods of brain stimulation for treating depression

  This study is testing if a personalized brain stimulation method can help people with major depressive disorder feel better compared to the standard treatment.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT06152705

• Infliximab treatment for cognitive dysfunction in depressed individuals with inflammation

  This study is testing if infliximab can help improve thinking and memory in adults with depression who also have signs of inflammation.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT06136546

• Telehealth exercise program to treat depression after brain injury

  This study tests whether a telehealth exercise program can help people with depression after a brain injury feel better by encouraging them to be more active.

  Recruiting University of Washington · Seattle, Washington · NCT06005194

• Exploring how ketamine's effects on depression relate to AMPA receptors

  This study is testing if blocking certain brain receptors affects how well ketamine helps people with depression who haven't responded to other treatments.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT05915013

• Dopamine's effect on motivation and motor function in major depression and inflammation

  This study tests if a medication that boosts dopamine can help improve motivation and movement in people with major depression and inflammation.

  Recruiting Charite University, Berlin, Germany · Steglitz · NCT05909267

• Identifying predictors for treatment response in major depression

  This study is trying to find out what factors can help predict how well different treatments will work for people with major depression.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05616559

• Using rTMS to Treat Depression in Veterans with Spinal Cord Injuries

  This study is testing a new way to use brain stimulation to help veterans with spinal cord injuries who are struggling with depression.

  Recruiting VA Office of Research and Development · Charleston, South Carolina · NCT05553353

• Training veterans with serious mental illness to improve social skills for work

  This study is testing a special training program to help veterans with serious mental illnesses improve their social skills for better job interactions.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT05491538

• Nociceptin receptor blockade to change approach and avoidance behavior in depression and anxiety.

  This trial will test whether a drug that blocks the nociceptin receptor can normalize brain signals and help unmedicated adults with major depression or anxiety make more balanced approach/avoidance decisions.

  Recruiting Phase 2 Mclean Hospital · Belmont, Massachusetts · NCT05232032

• Mitizodone Phosphate tablets for major depressive disorder

  This study will try Mitizodone Phosphate tablets in adults with major depressive disorder to see if they improve depressive symptoms compared with placebo.

  Recruiting Phase 2/3 Sunshine Lake Pharma Co., Ltd. · Dongguan, Guangdong · NCT04984512

• Treatment for depression in borderline personality disorder using brain stimulation

  This study is testing if a special type of brain stimulation can help people with borderline personality disorder and depression feel better.

  Recruiting Stanford University · Stanford, California · NCT04870255

• Identifying biomarkers for major depression and treatment response

  This study is trying to find specific brain markers that can help identify major depression and how well people respond to a new therapy called TMS.

  Recruiting University of California, San Francisco · San Francisco, California · NCT04581902

• Finding the best electrical pulse for electroconvulsive therapy in depression

  This study is testing whether a longer electrical pulse during electroconvulsive therapy can help people with depression feel better while causing fewer memory problems.

  Recruiting Phase 4 Region Örebro County · Örebro · NCT04057378

• Nitrous oxide targets brain circuits involved in mood

  This research will test whether inhaled nitrous oxide changes brain connectivity and improves symptoms in adults with treatment-resistant major depression compared with healthy volunteers.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT02994433

Related topics

Quick answers

How many Depressive Disorder, Major clinical trials are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 34 countries. The most sites are in United States (17 trials), Canada (6 trials), China (5 trials), Brazil (5 trials), Germany (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 6, Phase 2: 3, Phase 1: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →