Finding the best electrical pulse for electroconvulsive therapy in depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify the optimal electrical pulse width during electroconvulsive therapy (ECT) for patients with major depressive disorder or bipolar disorder. It compares two pulse widths, 0.5 ms and 1.0 ms, to determine which one results in better antidepressant effects while minimizing memory disturbances. The study is a national, register-based randomized trial with 800 participants, divided into two treatment arms, and evaluates various outcomes including remission rates and self-rated health. The primary objective is to see if the 1.0 ms pulse width leads to a higher remission rate compared to the 0.5 ms pulse width within one week after treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At least 18 years old at the time of inclusion
* Fulfilled diagnostic criteria for unipolar, or bipolar depressive episode according to ICD-10.
* Has indication for and accepts ECT
* Has a Swedish personal identity number
* Capable of giving informed consent

Exclusion Criteria:

• If the investigator judges a certain pulse width to be inappropriate for the patient.

Where it's running

• University hospital Örebro
  Örebro, Sweden Recruiting

Study contacts

• Principal investigator: Axel Nordenskjöld — Örebro University, Region Örebro län
• Study coordinator: Axel Nordenskjöld, MD, PhD
• Email: axel.nordenskjold@regionorebrolan.se
• Phone: +46196021000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.