Using rTMS to Treat Depression in Veterans with Spinal Cord Injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for major depressive disorder in individuals who have experienced spinal cord injuries (SCI). The study aims to develop a novel dosing technique for rTMS that does not rely on motor responses, which is crucial since many SCI patients have upper extremity impairments. By focusing on this specific population, the trial seeks to improve treatment accessibility and effectiveness for those suffering from depression post-SCI. The study will assess the antidepressant effects of rTMS in eligible participants over a defined period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* cervical or thoracic spinal cord injury at least 6 months prior with AIS A, B, C, or D;
* 18 - 60 years of age;
* major depressive disorder, as identified by Structured Clinical Interview for DSM-V;
* Hamilton Depression Rating Scale-17 score \> 18;
* not taking antidepressant medications or no change in doses of psychotropic medication(s) for at least 4 weeks before the study (6 weeks if newly initiated medication)

Exclusion Criteria:

* concomitant neurologic diseases/disorders or dementia;
* cognitive impairment (Montreal Cognitive Assessment \<17);
* history of psychosis or other Axis I disorder that is primary;
* positive screen for bipolar disorder through the Mini-International Neuropsychiatric Interview;
* history of claustrophobia;
* life expectancy \<1 year;
* electronic or metallic implants (i.e., metal in the head, cochlear implant, or pacemaker;
* history of seizures or currently prescribed anti-seizure medications;
* taking medication that increases the risk of seizures;
* pregnancy as identified through a positive urine pregnancy test;
* Hamilton Depression Rating Scale-17 question #3 regarding suicide: \>2 or suicide attempt within the previous two years;
* inability to (University of California, San Diego Brief Assessment of Capacity to Consent) or declined to give informed consent.

Where it's running

• Ralph H. Johnson VA Medical Center, Charleston, SC
  Charleston, South Carolina, United States Recruiting

Study contacts

• Principal investigator: Catherine J VanDerwerker, PhD DPT PT — Ralph H. Johnson VA Medical Center, Charleston, SC
• Study coordinator: Catherine J VanDerwerker, PhD DPT PT
• Email: catherine.vanderwerker@va.gov
• Phone: (843) 792-5047

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.