Condition

BRCA Mutation clinical trials and research

• 9Clinical trials
• 6Countries

Newest BRCA Mutation clinical trials

All recruiting trials (9)

• Comparing MiniLap and Standard Laparoscopy for Preventive Surgery in BRCA-Mutated Patients

  This study tests whether a smaller surgical technique called MiniLap is better than standard laparoscopy for patients with BRCA mutations who are having preventive surgery to remove their ovaries and fallopian tubes.

  Recruiting Azienda Sanitaria-Universitaria Integrata di Udine · Udine, Udine · NCT06831747

• Measuring circulating mutation burden (cfMB) in women with BRCA mutations and their sisters

  This trial will test whether a blood test that measures circulating mutation burden (cfMB) differs between cancer-free women who carry a BRCA1/2 mutation and their non-carrier sisters.

  Recruiting Centre Francois Baclesse · Caen, France · NCT06792721

• Using Olaparib for Advanced Prostate Cancer

  This study is testing how well the drug olaparib works for men with advanced prostate cancer who have specific genetic changes, to see if it helps them live longer and feel better.

  Recruiting at 2 sites Santa Chiara Hospital · Naples and 1 other locations · NCT06783127

• SYN818 for advanced or metastatic solid tumors

  This Phase 1 study will test oral SYN818 in adults with advanced or metastatic solid tumors, including breast, ovarian, and prostate cancers, whose standard treatments have been exhausted.

  Recruiting at 2 sites Phase 1 Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd · Zhengzhou, Henan and 1 other locations · NCT06666270

• Polygenic Risk Scores and Early Detection for Ovarian Cancer in BRCA1/2 Carriers

  This study tests how women with BRCA1/2 mutations feel about using polygenic risk scores and early-detection tests to guide cancer screening and risk-reducing decisions.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06436248

• Testing a new drug ETX-19477 for advanced solid tumors

  This study is testing a new drug called ETX-19477 to see if it can help people with advanced solid tumors that haven't responded to other treatments.

  Recruiting at 14 sites Phase 1/2 858 Therapeutics, Inc. · Phoenix, Arizona and 13 other locations · NCT06395519

• Predicting BRCA gene status from healthy ovarian ultrasound images

  This study is testing if ultrasound images of healthy ovaries can help predict whether women carry the BRCA gene that increases their risk for breast cancer.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT05769517

• New treatment approach for BRCA1/2 mutated triple negative breast cancer

  This study is testing a new treatment combining Olaparib and Pembrolizumab for people with BRCA1/2 mutated triple negative breast cancer to see if it works better after chemotherapy.

  Recruiting at 3 sites Phase 2 Okayama University · Gifu, Gifu and 2 other locations · NCT05485766

• Imaging study using FCH-PET-CT in men with prostate cancer and DNA repair gene mutations

  This study is testing if a new type of imaging called FCH-PET-CT can better find cancer spread in men with prostate cancer who have certain gene mutations compared to regular imaging methods.

  Recruiting Institute of Cancer Research, United Kingdom · London, Sutton, Surrey · NCT05097274

Related topics

Quick answers

How many BRCA Mutation clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in Italy (3 trials), United States (2 trials), France (1 trial), United Kingdom (1 trial), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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