Condition

Breast Cancer Stage IV clinical trials and research

• 16Clinical trials
• 13Countries

Newest Breast Cancer Stage IV clinical trials

All recruiting trials (16)

• ctDNA-guided sequential anti-HER2 therapy with CNS prophylaxis for HER2-positive metastatic breast cancer

  This trial will test whether using regular ctDNA blood tests to guide stepping up or down sequential anti-HER2 treatments, together with local therapies and measures to protect the brain and spinal cord, can produce long-lasting remission for people with HER2-positive stage IV breast cancer.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07459673

• Trastuzumab deruxtecan plus pertuzumab with proactive side-effect monitoring for first-line HER2-positive metastatic breast cancer

  This trial will try trastuzumab deruxtecan together with pertuzumab and digital tools to catch and manage side effects early in people starting first-line treatment for HER2-positive metastatic breast cancer.

  Recruiting at 12 sites Phase 2 SOLTI Breast Cancer Research Group · Villejuif and 26 other locations · NCT07371585

• Meaning-Centered Therapy for Latinos for adults with advanced cancer

  This study tests whether Meaning-Centered Psychotherapy for Latinos (MCP-L) can reduce anxiety and depression and improve quality of life compared with CBT in Spanish-speaking adults with advanced cancer.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York and 1 other locations · NCT07225309

• Radiology-based prediction of HER2 level and T‑DXd benefit in metastatic breast cancer

  This study tests whether patterns in CT or FDG‑PET images can show HER2 level and help predict response to trastuzumab deruxtecan for people with metastatic breast cancer.

  Recruiting Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan · NCT07030569

• Camrelizumab plus apatinib and eribulin versus physician's choice chemotherapy for advanced triple-negative breast cancer

  This trial tests whether combining camrelizumab, apatinib, and eribulin works better than your doctor's chosen chemotherapy for adults with advanced triple-negative breast cancer who have had 1–4 prior systemic treatments.

  Recruiting at 5 sites Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong and 6 other locations · NCT06889688

• Using HER2-PET imaging to guide HER2-ADC treatment in metastatic HER2-expressing breast cancer

  This trial will test whether HER2-targeted PET imaging can help find people with metastatic HER2-expressing breast cancer who should get the HER2-directed antibody‑drug conjugate T‑DXd.

  Recruiting Karolinska University Hospital · Solna · NCT06830382

• Predicting outcomes for advanced breast cancer patients treated with CDK4/6 inhibitors and endocrine therapy

  This study is trying to see how well different CDK4/6 inhibitors combined with hormone therapy work for people with advanced breast cancer and how safe they are.

  Recruiting at 24 sites Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Aviano and 23 other locations · NCT06805812

• Detecting Tumor DNA in Blood to Find T-DXd Candidates in HR+/HER2-Low Metastatic Breast Cancer

  We test whether persistent tumor DNA in blood after starting standard therapy can identify HR+ HER2-low metastatic breast cancer patients who may benefit from trastuzumab deruxtecan.

  Recruiting at 12 sites Phase 2 Unicancer · Amiens and 39 other locations · NCT06680596

• Testing Abemaciclib with Radiation Therapy for Metastatic Breast Cancer

  This study is testing different doses of the drug abemaciclib in people with metastatic breast cancer who are also getting hormone therapy and radiation to see if it helps them better manage their symptoms.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06678269

• Using tart cherry juice to prevent nerve damage from chemotherapy in breast cancer patients

  This study is testing if drinking tart cherry juice can help prevent nerve damage in breast cancer patients receiving chemotherapy.

  Recruiting Phase 2 University of California, Davis · Sacramento, California · NCT06268665

• Combining pembrolizumab with cryoablation for metastatic breast cancer

  This study is testing if combining a drug called pembrolizumab with a freezing treatment can help people with advanced triple negative breast cancer feel better compared to just using the drug alone.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06246968

• Treatment for advanced or metastatic breast cancer using sacituzumab govitecan

  This study is testing if a new drug called sacituzumab govitecan can help people with advanced breast cancer who haven't had success with other treatments.

  Recruiting at 2 sites Phase 2 SOLTI Breast Cancer Research Group · Badalona, Barcelona and 9 other locations · NCT06236269

• Oral MBQ-167 treatment for advanced breast cancer

  This study is testing a new oral medication called MBQ-167 to see if it can help people with advanced breast cancer who haven't had success with other treatments.

  Recruiting at 3 sites Phase 1 MBQ Pharma · Beverly Hills, California and 3 other locations · NCT06075810

• Testing FWD1802 for ER+/HER2- breast cancer

  This study is testing a new treatment called FWD1802, alone and with another drug, to see if it can help people with advanced ER+/HER2- breast cancer feel better and improve their outcomes.

  Recruiting at 20 sites Phase 1/2 Forward Pharmaceuticals Co., Ltd. · Hefei, Anhui and 21 other locations · NCT06064812

• Stereotactic Ablative Radiotherapy for Oligometastatic Breast Cancer

  This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with oligometastatic breast cancer live longer and feel better.

  Recruiting at 19 sites Phase 3 Vastra Gotaland Region · Cork and 18 other locations · NCT05377047

• Treatment for metastatic cancer with BRCA or PALB2 mutations using chemotherapy and stem cells

  This study is testing a new treatment combining chemotherapy and stem cells for people with metastatic pancreatic or breast cancer who have BRCA or PALB2 mutations to see if it is safe and effective.

  Recruiting Phase 1 General Oncology, Inc. · Boston, Massachusetts and 1 other locations · NCT04150042

Related topics

Quick answers

How many Breast Cancer Stage IV clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (7 trials), Italy (3 trials), Sweden (2 trials), France (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 4, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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