PEEP tuning in acute respiratory failure using CT and EIT data
Official title: Association Between the "Best" Positive End-Expiratory Pressure Identified With Electrical Impedance Tomography and the Potential for Hyperinflation and Collapse Assessed With Lung Computed Tomography in Mechanically Ventilated Patients With Acute Respiratory Failure
Run by Istituto Clinico Humanitas · NCT07175194 · Data updated 2026-11-12
Researchers will look at routine CT and electrical impedance tomography data from adults on mechanical ventilation to see how different PEEP levels relate to lung information, without any new interventions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Istituto Clinico Humanitas Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Milan, Milan) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | March 2027 |
| Study ends | June 2027 |
| Registry record updated | May 19, 2026 |
| Trial ID | NCT07175194 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with acute respiratory failure on mechanical ventilation who have both a lung CT and EIT performed to guide PEEP as part of routine practice.
✕Probably not a fit
Patients without access to CT or EIT or those for whom imaging cannot be performed due to safety or medical reasons may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational analysis of data already collected during standard care for adults with acute respiratory failure requiring mechanical ventilation. The study combines CT imaging and electrical impedance tomography to explore how PEEP settings correspond to lung characteristics. No additional procedures or interventions are required beyond what is already done in clinical practice. The goal is to understand whether using combined imaging signals can inform better PEEP choices and potentially improve outcomes in ARF patients.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor PEEP more precisely by leveraging imaging information gathered during routine care.
How similar studies have gone: Previous work has explored CT and EIT separately for ventilation settings, but combining them in routine practice for PEEP guidance is relatively novel, with some supportive but not definitive prior signals.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥18 years of age) admitted to our Unit with ARF treated with mechanical ventilation * The patient undergoes a lung CT and EIT to guide the setting of PEEP as part of our routine clinical practice Exclusion Criteria: * The patient cannot undergo a lung CT and/or EIT as judged by the attending physician (for instance, transport to the radiology unit may be considered too risky if the patient is extremely severe, or using EIT may be contraindicated because of the presence of a pacemaker) * Pregnancy (as this condition alters the respiratory physiology)
Where it's running
-
IRCCS Humanitas Research Hospital
Milan, Milan, Italy Recruiting
Study contacts
- Study coordinator: Alessandro Protti
- Email: alessandro.protti@hunimed.eu
- Phone: +39 02 82244135
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.