Predicting HFNC Failure in Acute Hypoxemic Respiratory Failure using Metabolomics and Clinical Data

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study enrolls adults with acute hypoxemic respiratory failure who are started on HFNC in the ICU. Researchers collect clinical, physiological, and laboratory data, plus blood samples for metabolomic analysis, to identify patterns associated with HFNC failure. The aim is to build models that combine metabolomic and clinical information to predict escalation of respiratory support and important outcomes. Primary goals are to identify predictors of HFNC failure; secondary goals include associations with intubation, duration of support, ICU stay, and mortality. The study seeks to support personalized respiratory management for AHRF.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years old).
* Admission to the intensive care unit (ICU) with acute hypoxemic respiratory failure (AHRF).
* Treatment with high-flow nasal cannula (HFNC) as the initial respiratory support strategy.
* Inclusion within the first 24 hours after HFNC initiation.
* Provision of informed consent by the patient or legally authorized representative.

Exclusion Criteria:

* Age \<18 years.
* Active do-not-resuscitate (DNR) orders or limitation of therapeutic effort.
* Refusal or inability to provide informed consent.
* Previous invasive mechanical ventilation before study inclusion.

Where it's running

• Hospital del Mar
  Barcelona, Catalonia, Spain Recruiting

Study contacts

• Principal investigator: Francisco José Parrilla-Gómez, MD, Phd — Hospital del Mar
• Study coordinator: Francisco José Parrilla-Gómez, MD, Phd
• Email: fparilla@hmar.cat
• Phone: +34 747424848

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.