Identifying subtypes of acute hypoxemic respiratory failure in emergency patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on critically ill patients who present to the emergency department with de novo acute hypoxemic respiratory failure (AHRF). The researchers aim to perform dynamic endotyping to classify patients based on clinical, radiological, physiological, and biological variables collected early in their condition. By understanding these endotypes, the study seeks to correlate them with outcomes such as mortality and persistent severe hypoxemia, addressing the heterogeneity of AHRF and potentially guiding future treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (aged \>18 years) presenting in the emergency department
* De novo acute hypoxemic respiratory failure (requiring oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more)

Exclusion Criteria:

* Age \<18 years
* Not admitted to the hospital
* Postoperative acute respiratory failure (within one week from surgery)
* Chronic hypoxemic respiratory failure (requiring long term oxygen therapy at home)
* Hypercapnic respiratory failure
* Transferred from another hospital or facility
* Pregnant women
* Admitted to the hospital purely to facilitate comfort care
* Lack of informed consent

Where it's running

• Evangelismos Hospital
  Athens, Attica, Greece Recruiting

Study contacts

• Principal investigator: Ilias I. Siempos, MD, DSc — Evangelismos Hospital
• Study coordinator: Eleni D. Papoutsi, MD
• Email: helenapapoutsi@gmail.com
• Phone: +306981173761

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.