Identifying subtypes of acute hypoxemic respiratory failure in emergency patients
EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure
This study is trying to identify different types of acute respiratory failure in emergency patients to see how these types affect their chances of recovery and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Evangelismos Hospital Academic / other |
| Locations | 1 site (Athens, Attica) |
| Trial ID | NCT05150483 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on critically ill patients who present to the emergency department with de novo acute hypoxemic respiratory failure (AHRF). The researchers aim to perform dynamic endotyping to classify patients based on clinical, radiological, physiological, and biological variables collected early in their condition. By understanding these endotypes, the study seeks to correlate them with outcomes such as mortality and persistent severe hypoxemia, addressing the heterogeneity of AHRF and potentially guiding future treatment strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who present with de novo acute hypoxemic respiratory failure requiring significant oxygen support.
Not a fit: Patients who may not benefit include those under 18 years old, those with chronic hypoxemic respiratory failure, or those admitted solely for comfort care.
Why it matters
Potential benefit: If successful, this study could lead to improved patient outcomes by identifying specific subtypes of AHRF that may respond differently to treatments.
How similar studies have performed: While there have been efforts to endotype ARDS, this approach is novel in its dynamic assessment of AHRF in an emergency setting.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (aged \>18 years) presenting in the emergency department * De novo acute hypoxemic respiratory failure (requiring oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more) Exclusion Criteria: * Age \<18 years * Not admitted to the hospital * Postoperative acute respiratory failure (within one week from surgery) * Chronic hypoxemic respiratory failure (requiring long term oxygen therapy at home) * Hypercapnic respiratory failure * Transferred from another hospital or facility * Pregnant women * Admitted to the hospital purely to facilitate comfort care * Lack of informed consent
Where this trial is running
Athens, Attica
- Evangelismos Hospital — Athens, Attica, Greece (Recruiting)
Study contacts
- Principal investigator: Ilias I. Siempos, MD, DSc — Evangelismos Hospital
- Study coordinator: Eleni D. Papoutsi, MD
- Email: helenapapoutsi@gmail.com
- Phone: +306981173761
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.