Condition

ACL Reconstruction clinical trials and research

• 12Clinical trials
• 12NIH research projects
• 8Countries

Newest ACL Reconstruction clinical trials

All recruiting trials (12)

• Plyometric training added to standard rehab after ACL reconstruction

  This study tests whether adding plyometrics to the usual rehab after ACL reconstruction helps improve leg strength and function in adults aged 18–40.

  Recruiting Cairo University · Qina, Qena Governorate · NCT07862881

• Isokinetic vs Plyometric Training After ACL Reconstruction

  This trial tests whether isokinetic or plyometric training, added after standard rehab, best improves strength, function, and patient-reported outcomes in adults 18–40 after ACL reconstruction.

  Recruiting Cairo University · Qina, Qena Governorate · NCT07862868

• ACL reconstruction using the Over-The-Top technique with either metal staples or soft anchors

  This study tests whether using a suture-based fixation (soft anchors) during OTT ACL reconstruction works as well as metal staples for graft stability in adults aged 18–50.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT07819929

• Arthroscopic ACL reconstruction with peroneus longus graft with or without a platelet-rich plasma (PRP) injection

  This test sees if a single 4 ml intra-articular PRP injection given during ACL reconstruction with a peroneus longus graft helps adults (18–50) with isolated ACL tears recover better over 12 months.

  Recruiting Phase 2 Lahore General Hospital · Lahore, Punjab Province · NCT07470359

• Movement-related fear after ACL reconstruction: general kinesiophobia versus task-specific sport fear

  This trial will test whether visual and imagined movement exposures reveal task-specific fear versus general kinesiophobia in people aged 18–35 recovering from ACL reconstruction.

  Recruiting at 2 sites Egas Moniz - Cooperativa de Ensino Superior, CRL · Caparica, Almada and 1 other locations · NCT07190456

• ACL reconstruction with lateral extra‑articular tenodesis (LET): clinical and biomechanical outcomes

  This project will see if adding lateral extra‑articular tenodesis (LET) to ACL reconstruction changes knee stability and recovery in adults 18–50 who receive gracilis and semitendinosus grafts.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT07049484

• Focused shock wave therapy to help recovery after ACL surgery

  This program will test whether adding a weekly low‑intensity focused shock wave treatment to standard physiotherapy helps adults aged 18–45 regain strength, motion, balance, and reduce pain after ACL reconstruction with a hamstring graft.

  Recruiting Biruni University · Istanbul · NCT06688344

• Personalized 12-week digital exercise program to correct knee movement after ACL reconstruction

  This program will try a 12-week sensor-guided exercise plan for adults 8–12 weeks after ACL reconstruction to correct harmful knee movements and reduce joint inflammation that can lead to early knee osteoarthritis.

  Recruiting at 2 sites Charite University, Berlin, Germany · Berlin and 1 other locations · NCT06596824

• Assessing ACL healing after surgery with and without internal bracing

  This study is testing if using an internal brace during ACL surgery helps patients heal better compared to those who don’t get the brace.

  Recruiting NYU Langone Health · New York, New York · NCT06542705

• Protein supplementation after ACL surgery

  This study is testing if adding protein supplements after ACL surgery can help young patients keep their muscle size and strength as they recover.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06311058

• Investigating Alendronate's Effect on Knee Function After ACL Reconstruction

  This study is testing if the osteoporosis medication Alendronate can help people aged 18-40 recover better and improve knee function after their first ACL surgery.

  Recruiting Phase 4 Chinese University of Hong Kong · Shatin · NCT05527548

• Improving quadriceps function after knee surgery with blood flow restriction training

  This study is testing if adding blood flow restriction training to physical therapy can help people recovering from knee surgery feel stronger and recover better.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT03096366

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Graft Remodeling and Joint Degeneration after ACL Reconstruction in the Growing Knee Joint

  This grant focuses on how ACL reconstruction in growing kids and teens affects knee grafts and long-term joint health.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11416619

• Using clinic videos to spot risk of a second ACL injury after reconstruction

  This project uses easy-to-take clinic videos and wearable sensors to find movement patterns that may predict a second ACL injury in people who've had ACL reconstruction.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11261253

• Options for a second (revision) ACL surgery

  This work looks at how different surgical approaches and patient factors relate to long-term outcomes for people having a second ACL reconstruction.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11169935

• Improving quadriceps muscle function after ACL surgery using brain stimulation

  This study is looking at how a gentle brain stimulation technique can help improve the strength and function of your thigh muscles as you recover from ACL surgery, making your rehabilitation process easier and more effective.

  NIH research Arcadia University · Glenside, United States · NIH-11124552

• How walking and physical activity affect knee health after ACL surgery

  This study is looking at how walking and activity levels affect knee health in young adults who have had ACL surgery, aiming to find ways to prevent long-term pain and joint issues during their first year of recovery.

  NIH research Michigan State University · East Lansing, United States · NIH-11091593

• Predicting second injuries after ACL surgery using video technology

  This study is looking at how to help people who have had ACL surgery avoid getting hurt again by tracking their movements and activities for 18 months, so we can learn more about what might lead to a second injury.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11041104

• Improving walking patterns after ACL surgery

  This study is testing a new walking program to help people recover better after ACL surgery by teaching them a special way to walk that could make their knees feel better and prevent future problems.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-10909149

• Investigating knee joint health after ACL surgery using advanced imaging techniques

  This study is looking at how the health of your knee changes over time after ACL surgery, with the goal of finding early signs of arthritis that might develop later, and it involves over 3,500 people who will be followed for up to 10 years to help us understand their knee health better.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10878519

• Improving recovery after ACL surgery with exercise and mental support

  This study is testing a new way to help people recover from ACL surgery by combining exercise with emotional support, so patients can feel better both physically and mentally during their healing process.

  NIH research Healthpartners Institute · Bloomington, UNITED STATES · NIH-10800102

• Comparing a new device for ACL repair with standard surgery

  This study is looking at a new device called the BEAR to see if it works better than the usual surgery for fixing ACL injuries, and it's for people who have had this type of knee injury and want to know which treatment might help them heal and stay active longer.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10686051

• Investigating long-term knee joint health after ACL surgery using advanced imaging techniques

  This study is looking at how knee health changes over time for people who have had ACL surgery, using special MRI scans to find early signs of arthritis, so we can better understand and help manage knee problems for these patients.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10665556

• Understanding knee joint changes after ACL surgery and meniscus removal

  This study is looking at how surgeries for ACL tears and meniscus removal change how your knee works, with the goal of understanding what might lead to arthritis later on, so we can find better ways to help you heal and stay active.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-10347360

Related topics

Quick answers

How many ACL Reconstruction clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (3 trials), Italy (2 trials), Egypt (2 trials), Hong Kong (1 trial), Portugal (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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