Arthroscopic ACL reconstruction with peroneus longus graft with or without a platelet-rich plasma (PRP) injection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, prospective randomized controlled Phase 2 trial in Lahore, Pakistan will randomize 88 adults with isolated complete ACL tears to receive either a single 4 ml intra-articular PRP injection or saline at the time of arthroscopic ACL reconstruction with a peroneus longus autograft. PRP is prepared from 15–20 ml venous blood using a single-spin centrifugation (3500 rpm) and delivered as 2 ml per femoral/tibial tunnel during surgery. Functional recovery will be measured using KOOS4 questionnaires at baseline, 3, 6, and 12 months with primary comparisons made by ANCOVA adjusting for baseline scores. The trial is designed to be feasible in a resource-limited setting and integrates follow-up into routine clinic visits to minimize dropout.

Why it matters

Who can join: the full rules

Inclusion Criteria: Age between 18 and 50 years. Diagnosis of a primary, complete ACL tear requiring reconstruction. Willingness to undergo arthroscopic ACL reconstruction with peroneus longus autograft.

Active individuals participating in sports or regular physical activity. Willingness to provide informed consent and adhere to the study protocol, including follow-up visits and rehabilitation.

Ability to understand and complete study questionnaires. - Exclusion Criteria: Previous knee surgery on the affected limb. Concomitant ligamentous injuries requiring additional reconstruction (e.g., PCL, MCL, LCL Grade III).

Significant chondral damage (Outerbridge grade \> 2 on pre-operative MRI or intra-operative assessment).

Pre-existing knee osteoarthritis (Kellgren-Lawrence grade \> 2). Systemic inflammatory conditions (e.g., rheumatoid arthritis). Bleeding disorders or coagulopathies. Current use of anticoagulants. Corticosteroid injection into the knee within 6 weeks prior to surgery. Pregnancy or lactation. Inability to comply with the rehabilitation protocol. Infection or history of infection in the affected knee. History of previous contralateral ACL injury (to isolate primary injury outcomes).

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Where it's running

• Lahore General Hospital
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Hafiz Sohail Ahmad, Dr
• Email: Hafiz.sohail.315@gmail.com
• Phone: +923204085069

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.