Clinical trial Recruiting at 1 site Interventional Ages 14 to 55

Improving quadriceps function after knee surgery with blood flow restriction training

Official title: Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery? A Randomized Clinical Trial

Run by The University of Texas Health Science Center, Houston · NCT03096366 · Data updated 2026-11-12

This study is testing if adding blood flow restriction training to physical therapy can help people recovering from knee surgery feel stronger and recover better.

Quick facts

Study typeInterventional
Ages14 Years to 55 Years
SexAll
Enrollment150 (estimated)
SponsorThe University of Texas Health Science Center, Houston
Academic / other
Locations1 site (Houston, Texas)
StatusRecruiting
StartedNovember 21, 2017
Main results expectedDecember 2022
Study endsDecember 2022
Registry record updatedMay 4, 2022
Trial IDNCT03096366 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals undergoing ACL reconstruction with additional meniscus or cartilage procedures who are expected to return to sports.

Probably not a fit

Patients who cannot participate in physical therapy or have conditions such as pregnancy or malignancy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of combining physical therapy with blood flow restriction (BFR) training compared to physical therapy alone in patients recovering from anterior cruciate ligament (ACL) reconstruction. The focus is on patients who are required to limit weight bearing after surgery. The study aims to assess patient-reported outcomes and functional testing to determine if BFR training can help mitigate quadriceps muscle atrophy and improve recovery outcomes. The hypothesis is that the addition of BFR training will enhance muscle strength and function during rehabilitation.

Why it matters

Potential benefit: If successful, this approach could lead to improved recovery and muscle function for patients after knee surgery.

How similar studies have gone: Other studies have shown promising results with blood flow restriction training in rehabilitation, suggesting potential effectiveness in this context.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Anterior cruciate ligament (ACL) reconstruction with concomitant meniscus or cartilage restoration procedures
* Adherence to modified weight bearing status before initiation of PT
* Expected participation in recreational or competitive sports after release to full activities

Exclusion Criteria:

* Unable to attend (or participate in) physical therapy
* Pregnancy
* Malignancy
* Fracture
* Peripheral vascular disease
* History of deep vein thrombosis (DVT)

Where it's running

  • The University of Texas Health Science Center at Houston
    Houston, Texas, United States
    Recruiting

Study contacts

  • Principal investigator: Walter R Lowe, MD — The University of Texas Health Science Center, Houston
  • Study coordinator: Walter R Lowe, MD
  • Email: walter.r.lowe@uth.tmc.edu
  • Phone: 713-486-6844

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.