Improving quadriceps function after knee surgery with blood flow restriction training
Official title: Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery? A Randomized Clinical Trial
Run by The University of Texas Health Science Center, Houston · NCT03096366 · Data updated 2026-11-12
This study is testing if adding blood flow restriction training to physical therapy can help people recovering from knee surgery feel stronger and recover better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years to 55 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | November 21, 2017 |
| Main results expected | December 2022 |
| Study ends | December 2022 |
| Registry record updated | May 4, 2022 |
| Trial ID | NCT03096366 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals undergoing ACL reconstruction with additional meniscus or cartilage procedures who are expected to return to sports.
✕Probably not a fit
Patients who cannot participate in physical therapy or have conditions such as pregnancy or malignancy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of combining physical therapy with blood flow restriction (BFR) training compared to physical therapy alone in patients recovering from anterior cruciate ligament (ACL) reconstruction. The focus is on patients who are required to limit weight bearing after surgery. The study aims to assess patient-reported outcomes and functional testing to determine if BFR training can help mitigate quadriceps muscle atrophy and improve recovery outcomes. The hypothesis is that the addition of BFR training will enhance muscle strength and function during rehabilitation.
Why it matters
Potential benefit: If successful, this approach could lead to improved recovery and muscle function for patients after knee surgery.
How similar studies have gone: Other studies have shown promising results with blood flow restriction training in rehabilitation, suggesting potential effectiveness in this context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Anterior cruciate ligament (ACL) reconstruction with concomitant meniscus or cartilage restoration procedures * Adherence to modified weight bearing status before initiation of PT * Expected participation in recreational or competitive sports after release to full activities Exclusion Criteria: * Unable to attend (or participate in) physical therapy * Pregnancy * Malignancy * Fracture * Peripheral vascular disease * History of deep vein thrombosis (DVT)
Where it's running
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The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Walter R Lowe, MD — The University of Texas Health Science Center, Houston
- Study coordinator: Walter R Lowe, MD
- Email: walter.r.lowe@uth.tmc.edu
- Phone: 713-486-6844
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Plyometric training added to standard rehab after ACL reconstruction
This study tests whether adding plyometrics to the usual rehab after ACL reconstruction helps improve leg strength and function in adults aged 18–40.
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Isokinetic vs Plyometric Training After ACL Reconstruction
This trial tests whether isokinetic or plyometric training, added after standard rehab, best improves strength, function, and patient-reported outcomes in adults 18–40 after ACL reconstruction.
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ACL reconstruction using the Over-The-Top technique with either metal staples or soft anchors
This study tests whether using a suture-based fixation (soft anchors) during OTT ACL reconstruction works as well as metal staples for graft stability in adults aged 18–50.
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Arthroscopic ACL reconstruction with peroneus longus graft with or without a platelet-rich plasma (PRP) injection
This test sees if a single 4 ml intra-articular PRP injection given during ACL reconstruction with a peroneus longus graft helps adults (18–50) with isolated ACL tears recover better over 12 months.
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Movement-related fear after ACL reconstruction: general kinesiophobia versus task-specific sport fear
This trial will test whether visual and imagined movement exposures reveal task-specific fear versus general kinesiophobia in people aged 18–35 recovering from ACL reconstruction.
-
ACL reconstruction with lateral extra‑articular tenodesis (LET): clinical and biomechanical outcomes
This project will see if adding lateral extra‑articular tenodesis (LET) to ACL reconstruction changes knee stability and recovery in adults 18–50 who receive gracilis and semitendinosus grafts.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.