Understanding knee joint changes after ACL surgery and meniscus removal
Biomechanical Markers of PTOA after ACL Reconstruction and Meniscal Resection
This study is looking at how surgeries for ACL tears and meniscus removal change how your knee works, with the goal of understanding what might lead to arthritis later on, so we can find better ways to help you heal and stay active.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10347360 on NIH RePORTER |
What this research studies
This research investigates how surgical procedures for anterior cruciate ligament (ACL) tears and meniscal removal affect the biomechanics of the knee joint. It aims to identify the specific changes in knee mechanics that may lead to post-traumatic osteoarthritis (PTOA) in patients. By analyzing the way cartilage and bones interact after surgery, the study seeks to uncover the underlying causes of PTOA, which could lead to better treatment options. Patients may undergo imaging and biomechanical assessments to gather data on their knee function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently undergone ACL reconstruction surgery, particularly those who also had meniscal injuries.
Not a fit: Patients who have not had ACL surgery or those with pre-existing osteoarthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing post-traumatic osteoarthritis in patients who have undergone ACL reconstruction and meniscal resection.
How similar studies have performed: While there is ongoing research into ACL injuries and osteoarthritis, this specific investigation into the biomechanical markers of PTOA post-surgery is relatively novel.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Fiorentino, Niccolo M — University of Vermont & St Agric College
- Study coordinator: Fiorentino, Niccolo M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.