Improving quadriceps muscle function after ACL surgery using brain stimulation

Determining the effects of non-invasive brain stimulation to improve quadriceps muscle function after ACL reconstruction.

['FUNDING_R15'] · ARCADIA UNIVERSITY · NIH-11124552

This study is looking at how a gentle brain stimulation technique can help improve the strength and function of your thigh muscles as you recover from ACL surgery, making your rehabilitation process easier and more effective.

Quick facts

Phase['FUNDING_R15']
Study typeNih_funding
SexAll
SponsorARCADIA UNIVERSITY (nih funded)
Locations1 site (GLENSIDE, UNITED STATES)
Trial IDNIH-11124552 on ClinicalTrials.gov

What this research studies

This research investigates how non-invasive brain stimulation can enhance quadriceps muscle function in patients recovering from anterior cruciate ligament (ACL) reconstruction. The study aims to address persistent muscle impairments that can lead to long-term complications like post-traumatic knee osteoarthritis. By applying a technique called anodal transcranial direct current stimulation (tDCS), the researchers hope to improve neural drive to the quadriceps, which may enhance rehabilitation outcomes. The project will involve monitoring muscle performance and movement patterns in participants to assess the effectiveness of this innovative approach.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who have recently undergone ACL reconstruction and are experiencing quadriceps muscle impairments.

Not a fit: Patients who have not had ACL surgery or those with pre-existing neurological conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved rehabilitation strategies that significantly enhance recovery and reduce the risk of long-term knee issues for ACL reconstruction patients.

How similar studies have performed: While the use of non-invasive brain stimulation in rehabilitation is a relatively novel approach, preliminary studies have shown promising results in enhancing muscle function in other contexts.

Where this research is happening

GLENSIDE, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: ACL injury, anterior cruciate ligament injury

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.