Options for a second (revision) ACL surgery
Revision ACL Reconstruction: A Comparative Effectiveness Treatment Study
This work looks at how different surgical approaches and patient factors relate to long-term outcomes for people having a second ACL reconstruction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11169935 on NIH RePORTER |
What this research studies
You would join a large group of people who had a revision (repeat) ACL reconstruction and be followed over many years. Doctors across dozens of centers collected patient-reported outcomes, clinical exams, and X-rays to track knee health and the development of post-traumatic osteoarthritis. A nested onsite group had detailed radiographic and clinical follow-up, and the project now adds genomic analyses to try to predict who is at higher risk for osteoarthritis. The study pools real-world surgical choices from many surgeons to help link technique and patient factors with long-term results.
Who could benefit from this research
Good fit: People who have had a prior ACL reconstruction and now need or have undergone a revision (second) ACL reconstruction are the ideal candidates.
Not a fit: People with a first-time (primary) ACL tear, unrelated knee conditions, or who are not having surgery would not be the focus and likely would not benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help surgeons pick treatments and identify patients at higher risk of osteoarthritis so care can be tailored to improve long-term knee health.
How similar studies have performed: Previous MARS cohort follow-ups at 2, 6, and 10 years produced important outcome and osteoarthritis findings, while using genomics to predict OA risk is a newer addition.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Wright, Rick W — Vanderbilt University Medical Center
- Study coordinator: Wright, Rick W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.