Sponsor or institution
Clinical trials and research at Univ of North Carolina Chapel Hill
As of November 12, 2026, Find a Trial lists 1,968 NIH-funded research projects at this institution, with $1.2 billion in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
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NIH-funded research (newest 40 of 1968)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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A center for coordinating data related to heart and blood health.
This study is working on a new system to gather and analyze health information about heart and blood disorders, which could lead to better ways to diagnose and treat these conditions, ultimately helping patients like you.
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Healthy work design and worker well-being
A multi-site program aims to improve the health and well-being of workers by studying how work design affects safety, stress, and quality of life.
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Unified and fair multimodal learning for autoimmune diseases
A patient-friendly AI approach will combine many kinds of health data to improve diagnosis and personalized care for autoimmune diseases, including lupus.
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Structural factors linking minimum wage, COVID-19, and community violence
A long-term study will explore whether higher minimum wages and pandemic-related economic factors are connected to changes in violence in US communities.
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Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
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How HPV interacts with our cells' DNA damage system and its effect on cancer
This project looks at how high-risk HPV uses the body’s DNA repair machinery to replicate and potentially drive cancer, with the goal of finding new antiviral and cancer-fighting approaches for people affected by HPV-related diseases.
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Post-flood malaria prevention: protecting kids and communities from malaria after heavy rains
A study tests new malaria prevention strategies after severe flooding to see if giving preventive medicine to children and reducing mosquito habitats can cut malaria in rural Uganda.
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Post-flood malaria prevention: protecting kids and communities from severe flooding impacts
A study in rural Uganda will test a malaria prevention plan after severe floods to see if giving a preventive medicine to children and using larval controls can lower malaria cases.
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Food allergy antibodies linked to heart disease risk in adults
Many adults have antibodies to foods without symptoms, and this study asks whether those antibodies are linked to higher risk of heart disease and related conditions.
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Population Center infrastructure to advance population dynamics research
A long-running research center at UNC Chapel Hill is requesting support to strengthen data resources, train junior scientists, and reduce administrative burden so it can study how populations grow, move, and are affected by inequality.
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Maternal mental health help to protect kids’ breathing health
A mother-focused mental health program is tested to see if improving moms’ mood can also support better breathing and fewer asthma symptoms in children.
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Rare bronchiectatic diseases: speeding smarter therapies for four rare lung conditions
A nationwide effort to understand four rare bronchiectatic diseases and identify biomarkers so future treatments can help people with these lung conditions.
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Rare bronchiectasis diseases: faster therapies for four rare lung conditions
A nationwide effort is studying four rare lung diseases that cause bronchiectasis to speed up the discovery of better treatments.
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Predicting how antimalarial drug resistance spreads with AI
A powerful AI model will be built to forecast how resistance to antimalarial drugs might spread in Africa and beyond, helping clinicians and public health teams stay ahead of outbreaks.
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How serotonin receptors affect retinal cells in glaucoma
This project studies how serotonin signals in the eye’s retina may influence glaucoma by looking at human and mouse retinal cells and how certain drugs touching serotonin pathways alter retinal function.
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Mondo: a community knowledgebase to standardize disease definitions for better diagnosis
A broad, collaborative effort to create a shared, computable map of diseases to help clinicians diagnose patients more accurately.
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How fentanyl and xylazine affect breathing and brain signals
A small, patient-friendly study will look at how dangerous opioid and animal-sedative combinations affect breathing and brain activity, which could help doctors manage overdoses better.
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Radon Exposure and Stroke: How a Home Gas Might Influence Brain Vascular Health
This project looks at whether radon exposure in homes is linked to stroke risk and brain vascular problems in people across the United States.
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Understanding alpha-gal meat allergy and how the body's immune system reacts
This grant studies why some people develop a dangerous allergy to meat due to a molecule called alpha-gal and how it triggers life-threatening reactions.
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Advancing Developmental Research with SEED Data to Understand ASD Across Ages
This grant uses the SEED data to learn how autism spectrum disorder appears and changes from early childhood through adolescence and adulthood in kids and families.
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Adventures in FASD Risk: new weekly alcohol exposure, parental factors, and maternal mental health
A health team is testing a new way to understand how a mother’s weekly alcohol use, her mental health, and a father’s alcohol exposure may shape fetal alcohol spectrum disorders in children.
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Molecular clues to progressive lung scarring
Researchers are studying how lung tissue becomes progressively scarred, focusing on cell signals and receptors that may drive fibrosis in people with lung disease.
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How School Environments Shape Youth Mental Health
This grant studies how primary school settings affect the mental health of children in the United States and Tanzania to find ways schools can support well-being.
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School environment factors affecting youth mental health
A long-term study following children and teens to see how schools influence mental health and resilience, in the United States and Tanzania.
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A brief alcohol support for PrEP users to boost HIV prevention
A short, friendly program helps people starting or restarting PrEP in Vietnam drink less and stick with PrEP to stay protected.
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Scaling up the brief alcohol support to prevent HIV in Vietnam
A nationwide plan in Vietnam tests a practical, clinic-based approach to help people with HIV reduce alcohol use and improve HIV control.
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Psychiatric genomics to understand and translate bipolar disorder biology
A large genetics project is studying how inherited DNA differences influence bipolar disorder and how this knowledge could lead to better care.
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Genomics and biology of psychiatric disorders to improve care
A large research effort will combine genetic data from many people to better understand why bipolar disorder and related conditions develop, with the goal of making future treatments and care more precise.
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Psychiatric Genomics: Linking Genes to Mental Health and Care
Big-picture genetics project to understand how genes influence serious mood and mental health conditions and how that knowledge can improve care for people with bipolar disorder.
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Genetics-driven understanding and translation of bipolar disorder
A big genetics project aims to uncover how inherited factors contribute to bipolar disorder and how that knowledge could be turned into better care.
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Genetics of psychiatric disorders: learning why bipolar conditions happen and how to use this for care
A broad team is studying the genes linked to bipolar disorder to better understand how these conditions arise and to translate discoveries into real-world care.
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Relapsing malaria in Africa: understanding persistence of relapsing species in Africa
A funded project in Africa and the U.S. seeks to understand why relapsing malaria species like P. vivax and P. ovale keep spreading, even as falciparum declines.
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Relapsing malaria in Africa: mechanisms for persistence amid falciparum decline
Researchers are studying why relapsing malaria from parasites like P. ovale and P. vivax continues to persist in Africa even as P. falciparum declines, and how this could affect future control efforts.
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Trans-Nordic look at extreme major depression genetics
A large genetics study is exploring what makes extreme forms of major depression unique, by studying many thousands of people and their DNA.
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CureGN-3: UNCPCC — following people with glomerular diseases to understand better treatments
A long-term, nationwide study follows adults and children with Berger's disease and related kidney diseases to learn about how they progress and respond to therapy.
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Artemisinin-resistant malaria in Ethiopia: who’s at risk and why it matters
This grant looks at why some malaria parasites in Ethiopia are harder to treat with standard artemisinin-based medicines and what that means for patients.
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Long-term Effects of a Natural Disaster on Cognitive Aging and Dementia in Older Adults
This project follows older adults affected by a major natural disaster to understand how long-term stress may influence aging, memory, and risk for dementia.
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Global HIV Prevention and Treatment Clinical Trials Unit at UNC
A UNC program dedicated to advancing HIV prevention and treatment through international clinical trials, engaging patients and communities affected by HIV in the US and globally.
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Repeat eyelid surgery that helps TT patients with Bevel-Rotate Advancement Procedure
This grant tests whether a new eye-surgery method helps people needing repeat eyelid surgery to correct trachomatous trichiasis.
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CONNECT-A: A multi-component plan to reduce HIV risk by addressing alcohol use and mental health and economic stress in young men
A community-based program helps high-risk young men reduce unhealthy drinking, improve PrEP use, and tackle stress and mental health barriers to HIV prevention.
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