Sponsor or institution
Clinical trials and research at The University of Texas Health Science Center at San Antonio
As of November 12, 2026, Find a Trial lists 74 clinical trials run by The University of Texas Health Science Center at San Antonio that are recruiting, in United States. By phase: Early Phase 1 (11), Phase 1 (8), Phase 2 (8), Phase 4 (5). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 74Clinical trials
- 1Country
Newest trials
All recruiting trials (74)
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Rapid relief of suicidal thoughts with ketamine and a crisis plan in the emergency department
This study tests whether a single intramuscular dose of ketamine plus a brief Crisis Response Plan helps reduce suicidal thoughts in ED patients who are likely to be admitted.
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Aprepitant for CLIFAHDD in young children and adults
This early-phase, safety-focused study tests whether aprepitant can be safely taken daily by people with CLIFAHDD to see if it’s tolerable and may help daily living.
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Genetics of Skeletal Muscle Insulin Resistance
This study tests how insulin affects gene activity in skeletal muscle by taking muscle samples during a controlled insulin clamp in adults with normal glucose tolerance.
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Training behavioral health providers to deliver Written Exposure Therapy with web and AI support
This study tests whether web-based training with AI help helps providers learn to deliver Written Exposure Therapy to veterans with PTSD.
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Oil Pulling Mouthwash Reduction in Plaque and Inflammation
A mouthwash-based study will test whether GuruNanda oil pulling rinse can reduce plaque and gum inflammation and bleeding in healthy adults compared with a competitor mouthwash and a water placebo.
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mHealth tool to boost hormone therapy adherence for Latina breast cancer patients
A bilingual, culturally tailored smartphone app plus patient navigation is tested to help Latina women on hormone therapy take their medication as prescribed.
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Sleep effects of stellate ganglion block in military personnel undergoing prolonged exposure therapy for PTSD
This study tests how a stellate ganglion block affects sleep in active duty service members and veterans with PTSD who are receiving prolonged exposure therapy.
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Oil Pulling Mouthwash for whitening teeth in adults
This study tests whether GuruNanda Oil Pulling oral rinse can whiten teeth better than a competitor’s whitening mouthwash or a water-based rinse in healthy adults with tooth stains.
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Sleep and DBS: Testing Deep Brain Stimulation Effects on Sleep in Parkinson’s
This study tests how turning the Deep Brain Stimulation device on or off affects sleep quality in people with Parkinson’s who already have a DBS implant.
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Ketogenic diet before surgery for early-stage breast cancer
This will test whether following a ketogenic diet for three weeks before surgery changes the tumor environment in people with early-stage, postmenopausal breast cancer.
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Nebulized tranexamic acid to stop post-tonsillectomy bleeding in children
This study tests if breathing in a fine TXA mist can quickly stop bleeding after tonsil removal in kids, potentially reducing the need for additional procedures.
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Memantine and raloxifene to protect memory after brain radiation
This study tests whether adding memantine and raloxifene to brain radiation can help adults preserve memory better than radiation alone.
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TMS for persistent PTSD in 12–20-year-olds
This project will test whether transcranial magnetic stimulation (TMS) helps 12–20-year-olds who still have PTSD symptoms after completing trauma-focused therapy.
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Non‑trauma PTSD treatment for veterans and service members with mild or moderate TBI
This pilot will test a non‑trauma psychotherapy program to help veterans and service members with mild or moderate traumatic brain injury who have PTSD.
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Surgery to remove pancreatic cancer and a few liver or lung metastases
This trial tests whether giving NALIRIFOX chemotherapy first and then surgically removing the main pancreatic tumor and limited liver or lung metastases helps people with pancreatic cancer that has only a few metastases.
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Home-based passive heat therapy to improve cardiovascular health after spinal cord injury
This program will test whether regular passive heat sessions at home can improve blood vessel and heart health in adults with chronic spinal cord injury.
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Glucagon's effects on blood sugar in people with and without bariatric surgery
This study tests whether giving glucagon or blocking its receptor changes short-term blood sugar control in non-diabetic adults who either had bariatric surgery or did not.
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Adaptive, personalized PTSD care for veterans
This program will try different therapy sequences plus optional text-message homework reminders to see if switching treatments or sending prompts helps veterans with PTSD who aren't improving or are missing between-session homework.
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Healing and bone formation after tooth extraction with OsteoGen ridge preservation
This will see if a calcium apatite/collagen plug (OsteoGen) produces more new bone than a human bone allograft (70% FDBA/30% DFDBA) in adults having a single non‑molar tooth removed and later replaced with a dental implant.
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Avasopasem plus CDK4/6 inhibitor and hormonal therapy for metastatic HR+, HER2- breast cancer after progression
This trial tests whether adding avasopasem to a CDK4/6 inhibitor and hormonal therapy is safe and may help people with metastatic HR+, HER2- breast cancer who progressed on prior CDK4/6 plus hormone therapy.
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Deciding whether PTSD therapy or tinnitus therapy should come first for people with both conditions.
This project will try giving either PTSD therapy first then tinnitus therapy, or tinnitus therapy first then PTSD therapy, in veterans and active-duty adults with PTSD and bothersome chronic tinnitus to see which order helps more.
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BSI-082 Alone or with Trastuzumab Deruxtecan in Advanced Solid Tumors
This early-stage study tests BSI-082 by itself and then with Trastuzumab deruxtecan to see if higher doses are safe and tolerable in adults with advanced or metastatic solid tumors.
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Dapagliflozin, Pioglitazone, and Ketone Production in Type 1 Diabetes
This study tests whether adding pioglitazone to dapagliflozin in adults with type 1 diabetes can lessen liver glucose production, fat breakdown, and ketone production while on insulin.
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Using a surgical microscope to improve gum flap healing
This study will test whether using a digital surgical microscope helps adults needing periodontal flap surgery heal better than using dental loupes.
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Enamel matrix derivatives to thicken gum tissue around dental implants
We will test whether applying enamel matrix derivatives under the gum flap during implant uncovering makes gum tissue thicker and increases the width of keratinized mucosa in adults getting dental implants.
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Empagliflozin and pioglitazone effects on ketone production in type 2 diabetes
This test will see if adding pioglitazone blocks empagliflozin's increase in glucose production, fat breakdown, and ketone production in adults with type 2 diabetes.
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Empagliflozin effects on ketone production, liver glucose output, and fluid balance in type 2 diabetes
This trial will test whether taking empagliflozin makes the liver produce more glucose and the body break down fat and make ketones in people with type 2 diabetes when mild volume loss combines with lower insulin levels.
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How empagliflozin affects liver glucose production, fat breakdown, and nerve-related signals
This test will see if the diabetes pill empagliflozin raises liver glucose production, fat breakdown, and ketones in people with type 2 diabetes and whether adding medicines such as propranolol or pioglitazone can block those changes.
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Combining Loncastuximab and Roflumilast with R-CHOP for High-Risk Diffuse Large B-cell Lymphoma
This study is testing a new treatment plan that combines loncastuximab and roflumilast with standard chemotherapy to see if it helps people with high-risk diffuse large B-cell lymphoma do better.
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Shared decision making to pick PTSD therapy for active duty military
This project will try shared decision making to match active duty service members with one of three PTSD therapies (Prolonged Exposure, Cognitive Processing Therapy, or Written Exposure Therapy) and either daily or weekly sessions to see if that improves treatment start, completion, and symptom reduction.
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Home-based tDCS to help thinking and behavior in Huntington's disease
This project will test whether daily at-home transcranial direct current stimulation (tDCS) can help thinking and behavioral symptoms in adults with early-to-moderate Huntington's disease.
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Tirzepatide effects on muscle and blood-vessel health in older adults with obesity
This trial will try tirzepatide for six months in adults 50 and older with obesity but without diabetes to see if it changes muscle mass, strength, and blood vessel health.
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Home-based tDCS for mood symptoms in Alzheimer's disease
This research will try to see if 30-minute home-based transcranial direct current stimulation (tDCS) sessions improve mood and other affective symptoms in people 60 and older with mild-to-moderate Alzheimer's disease.
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Understanding blood markers for alcohol consumption
This study is testing if a blood marker called PEth can help us understand how much and how often people drink alcohol by looking at their blood after they consume alcohol in a lab.
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Behavioral therapy to improve HIV prevention in sexual minority individuals
This study is testing a new therapy to see if it can help sexual minority individuals reduce drug use and risky sexual behaviors while sticking to their HIV prevention medication.
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Effects of a diabetes drug on glucose levels in people with spinal cord injuries
This study is testing if a diabetes drug called semaglutide can help people with spinal cord injuries better manage their blood sugar levels and improve their overall health.
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Evaluating smart pump technology in adult ICUs
This study looks at how well smart pump technology works in adult ICUs by talking to nurses and testing the system to see if it helps reduce medication errors.
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Restoring youthful mTOR activity in older adults
This study will test whether taking rapamycin or everolimus can safely bring mTOR activity in healthy adults aged 65–90 closer to levels seen in younger people.
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New treatment using robot-guided magnetic stimulation for alcohol use disorder
This study is testing a new robot-guided treatment to help people with alcohol use disorder cut back on their drinking by targeting specific areas of the brain.
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Training to improve hearing after mild brain injuries
This study is testing if special training exercises can help people with mild brain injuries hear better in noisy places.
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Treatment for anger and aggression in military personnel after betrayal
This study tests a new treatment program to help active duty service members and veterans manage anger and aggression caused by feelings of betrayal in the military.
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Nebulized tranexamic acid to stop post-tonsillectomy bleeding in children
We will try a medicated mist (nebulized tranexamic acid) to stop bleeding after tonsillectomy in children aged 2 to 17.
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Behavioral treatment for insomnia in military personnel with mild traumatic brain injury
This study is testing two different types of therapy for insomnia to see which one helps active duty military personnel with mild traumatic brain injury sleep better.
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Treatment for advanced liver cancer with specific cirrhosis
This study is testing a new combination treatment for advanced liver cancer in patients with specific cirrhosis to see if it can help them better than current options, especially focusing on those from underserved communities.
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Improving balance in Parkinson's disease using blood flow restriction
This study is testing whether using blood flow restriction during balance exercises can help people with Parkinson's disease improve their walking, balance, and endurance.
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Helping people with prediabetes and obesity improve their health
This study is testing different affordable treatments to help people with prediabetes and obesity lower their blood sugar and lose weight.
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Comparing two treatments for recently diagnosed type 2 diabetes
This study is testing two different treatment combinations for people who have just been diagnosed with type 2 diabetes to see which one helps lower blood sugar levels better.
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SGLT2 medication and ketone effects on heart function in people with type 2 diabetes and reduced ejection fraction
This will test whether taking empagliflozin, which raises blood ketones, helps the heart pump and fill better in adults with type 2 diabetes and heart failure with reduced ejection fraction.
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Effects of oral ketones on heart function in patients with diabetes and heart failure
This study tests if taking ketone supplements can help improve heart function in people with diabetes and heart failure.
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Investigating the effects of SGLT2 inhibitors on ketogenesis and glucose production in diabetes
This study tests how a diabetes medication called empagliflozin affects fat and sugar production in people with type 1 and type 2 diabetes.
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Quitxt bilingual text-and-chat program to help young Latino adults quit smoking
This test tries to see if Quitxt, a bilingual, culturally tailored text-message and chat program, helps Latino young adults (ages 18–29) quit smoking compared with abbreviated texts and a referral to Yes Quit.
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Combining a nerve block with therapy for PTSD in military personnel
This study is testing if combining a nerve block with therapy can help military personnel and veterans with PTSD feel better.
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Effects of Pioglitazone on Heart Failure in Obese Type 2 Diabetics
This study is testing if the diabetes drug Pioglitazone can help improve heart function in obese people with type 2 diabetes and heart failure.
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Using ketamine and a crisis response plan to help suicidal patients in the emergency department
This study is testing whether a single dose of ketamine along with a crisis response plan can help adults in the emergency department who are having suicidal thoughts feel better compared to regular care.
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Comparing telehealth and in-person therapy for chronic headaches in veterans
This study is testing if therapy for chronic headaches delivered through telehealth is just as helpful as in-person therapy for veterans and active duty service members.
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Combining Tislelizumab and SX-682 for Treating Resectable Pancreatic Cancer
This study is testing if combining two treatments, tislelizumab and SX-682, can help shrink tumors in patients with newly diagnosed pancreatic cancer before they have surgery.
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Improving dementia treatment assessment methods
This study is testing a new way to see if donepezil can help people with dementia feel better by looking at their thinking skills and daily activities, while also checking if certain markers in the body play a role in how well the treatment works.
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Comparing two medications for treating psychosis in Parkinson's disease and dementia with Lewy bodies
This study is testing which of two medications, pimavanserin or quetiapine, works better to help people with psychosis caused by Parkinson's disease or dementia with Lewy bodies.
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Understanding brain changes during therapy for adolescent PTSD
This study is trying to see how trauma-focused therapy changes the brains of teenagers with PTSD to help improve their treatment.
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Impact of DHA and ARA Supplementation on Preterm Infants
This study tests if giving preterm infants a supplement of DHA and ARA right after birth can help improve their fat metabolism as they grow.
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Measuring liver metabolism in patients with diabetes and fatty liver
This study is testing if a medication called pioglitazone can improve liver metabolism in people with type 2 diabetes and fatty liver disease over 16 weeks.
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Improving resilience and readiness in military personnel
This study is testing a new training program to see if it can help military personnel in high-stress jobs become more resilient and perform better compared to standard training methods.
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Effects of SGLT2 Inhibitors and Ketones on Heart and Muscle Health
This study is testing if a diabetes medication can change ketone levels in people with Type 2 Diabetes and heart failure to see how it affects their heart and muscle health over 12 weeks.
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Using Imipramine and Lomustine to treat recurrent glioblastoma
This study is testing whether a combination of Imipramine and Lomustine can help people with recurrent glioblastoma whose tumors have continued to grow after other treatments.
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Treatment for recurrent glioblastoma using Sacituzumab Govitecan
This study is testing a new treatment called Sacituzumab Govitecan to see if it can help people with recurrent glioblastoma who haven't responded to standard therapies.
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Understanding disease and treatment in older adults with liver cancer
This study is trying to understand how liver cancer affects older adults and what treatments work best for them to help improve their care.
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Using vancomycin powder to prevent infections in open fractures in the emergency room
This study tests whether using vancomycin powder directly on open fracture wounds in the emergency room can help prevent infections better than regular IV antibiotics.
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Creating a living biobank of lung cancer organoids
This study is trying to create a collection of lung cancer samples from patients to help with future research and understand more about the disease.
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Genetic analysis of tumors related to pheochromocytoma and paraganglioma
This study is trying to find genetic changes in people with pheochromocytomas and paragangliomas to help improve diagnosis and treatment options for them and their families.
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Investigating treatments for pre-diabetes with impaired glucose tolerance and fasting glucose
This study is testing different medications to see if they can help people with pre-diabetes improve their blood sugar levels and prevent them from developing type 2 diabetes.
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Effects of bariatric surgeries on glucose metabolism
This study tests how gastric bypass and sleeve gastrectomy surgeries affect blood sugar control after meals in people with diabetes to see which surgery might work better.
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Understanding how gastric bypass surgery affects glucose metabolism
This study is trying to see how gastric bypass surgery helps people manage their blood sugar better by looking at certain hormones and their effects on insulin in patients who have had the surgery.
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Investigating how neural and hormonal factors affect insulin secretion after gastric bypass surgery
This study is trying to see how certain hormones and nerve signals affect insulin release in people who have had gastric bypass surgery, especially looking at those who experience low blood sugar compared to those who don’t and healthy individuals.
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Research on chromosome 18 abnormalities and their effects
This study is trying to see how chromosome 18 problems affect growth and brain development in children, and whether treatments can help improve their health and well-being.
Quick answers
How many clinical trials run by The University of Texas Health Science Center at San Antonio are recruiting right now?
74, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Early Phase 1: 11, Phase 1: 8, Phase 2: 8, Phase 4: 5. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.