Genetic analysis of tumors related to pheochromocytoma and paraganglioma
Official title: Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions
Run by The University of Texas Health Science Center at San Antonio · NCT03160274 · Data updated 2026-11-12
This study is trying to find genetic changes in people with pheochromocytomas and paragangliomas to help improve diagnosis and treatment options for them and their families.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | The University of Texas Health Science Center at San Antonio Academic / other |
| Locations | 1 site (San Antonio, Texas) |
| Status | Recruiting |
| Started | October 19, 2005 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT03160274 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with pheochromocytoma or paraganglioma, as well as their family members.
✕Probably not a fit
Patients without a confirmed diagnosis of pheochromocytoma, paraganglioma, or associated conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on identifying genetic mutations associated with pheochromocytomas and paragangliomas, which are tumors that can lead to hormone imbalances and hypertension. It aims to map novel susceptibility genes and explore the relationship between these genetic mutations and clinical features in affected patients. By conducting genetic screenings, the study seeks to improve diagnosis, therapeutic planning, and genetic counseling for patients and their families. The research is observational and involves patients with confirmed diagnoses or familial links to these tumors.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of genetic factors in pheochromocytomas and paragangliomas, leading to better diagnosis and management for patients.
How similar studies have gone: Previous studies have shown success in identifying genetic mutations related to similar tumors, indicating a promising avenue for this research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of pheochromocytoma and or paraganglioma * family member with diagnosis of pheochromocytoma and or paraganglioma * diagnosis of a pheochromocytoma- and or paraganglioma-associated condition * family member with diagnosis of a pheochromocytoma- and or paraganglioma-associated condition Exclusion Criteria: * unconfirmed diagnosis of pheochromocytoma and/or paraganglioma or associated condition
Where it's running
-
University of Texas Health Science Center
San Antonio, Texas, United States Recruiting
Study contacts
- Principal investigator: Patricia L Dahia, MD, PhD — The University of Texas Health Science Center at San Antonio
- Study coordinator: Patricia L Dahia, MD,PhD
- Email: dahia@uthscsa.edu
- Phone: 2105674866
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
NET- and somatostatin-targeted PET/SPECT imaging to find and stage neuroblastoma and pheochromocytoma/paraganglioma
This study will try different PET and SPECT tracers to see if they can accurately find and stage tumors in children and adults with neuroblastoma or pheochromocytoma/paraganglioma.
-
Combining Lutathera® and Olaparib for treating recurrent solid tumors in children and adolescents
This study is testing if combining Lutathera® with olaparib can help children and teenagers with hard-to-treat solid tumors that have certain receptors.
-
Registry for Rare Diseases
This study is creating a detailed registry to collect information on rare diseases like amyloidosis and sarcoidosis to help improve how they are diagnosed and treated.
-
Understanding genetic causes of neuroendocrine tumors in Mexican patients
This study is trying to find out the genetic changes that cause neuroendocrine tumors in Mexican patients to help develop better treatments.
-
Examining the immune system in hereditary pheochromocytoma and paraganglioma
This study is testing how the immune system works in people with pheochromocytoma and paraganglioma, especially those with a family history of these tumors, to see if it can help us find better treatments.
-
Advancing genomic medicine using electronic health records
This study is trying to see if using electronic health records and helpful reminders can get more patients tested for genetic conditions in a way that doctors can easily use.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.