Genetic analysis of tumors related to pheochromocytoma and paraganglioma
Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions
This study is trying to find genetic changes in people with pheochromocytomas and paragangliomas to help improve diagnosis and treatment options for them and their families.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Sex | All |
| Sponsor | The University of Texas Health Science Center at San Antonio Academic / other |
| Locations | 1 site (San Antonio, Texas) |
| Trial ID | NCT03160274 on ClinicalTrials.gov |
What this trial studies
This study focuses on identifying genetic mutations associated with pheochromocytomas and paragangliomas, which are tumors that can lead to hormone imbalances and hypertension. It aims to map novel susceptibility genes and explore the relationship between these genetic mutations and clinical features in affected patients. By conducting genetic screenings, the study seeks to improve diagnosis, therapeutic planning, and genetic counseling for patients and their families. The research is observational and involves patients with confirmed diagnoses or familial links to these tumors.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with pheochromocytoma or paraganglioma, as well as their family members.
Not a fit: Patients without a confirmed diagnosis of pheochromocytoma, paraganglioma, or associated conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of genetic factors in pheochromocytomas and paragangliomas, leading to better diagnosis and management for patients.
How similar studies have performed: Previous studies have shown success in identifying genetic mutations related to similar tumors, indicating a promising avenue for this research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of pheochromocytoma and or paraganglioma * family member with diagnosis of pheochromocytoma and or paraganglioma * diagnosis of a pheochromocytoma- and or paraganglioma-associated condition * family member with diagnosis of a pheochromocytoma- and or paraganglioma-associated condition Exclusion Criteria: * unconfirmed diagnosis of pheochromocytoma and/or paraganglioma or associated condition
Where this trial is running
San Antonio, Texas
- University of Texas Health Science Center — San Antonio, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Patricia L Dahia, MD, PhD — The University of Texas Health Science Center at San Antonio
- Study coordinator: Patricia L Dahia, MD,PhD
- Email: dahia@uthscsa.edu
- Phone: 2105674866
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.