Healing and bone formation after tooth extraction with OsteoGen ridge preservation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults who need a single non‑molar tooth extracted and plan to receive an implant will have the extraction socket filled with either a calcium apatite/collagen plug (OsteoGen) or a combination allograft (70% FDBA/30% DFDBA). After about 16 weeks of healing, the bone removed during standard implant osteotomy will be collected rather than discarded and analyzed for new bone formation. The amount of new vital bone within the socket will be compared between the two materials to determine which preserves or promotes bone better. Procedures and follow-up visits occur at the University of Texas Health Science Center at San Antonio School of Dentistry.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female patient aged 18 to 89
* One tooth, excluding molars, that has been identified by dental faculty as requiring a single tooth extraction
* A dental implant is indicated and treatment planned to replace the missing tooth
* Site has adequate restorative space for a dental implant-retained restoration
* Site has at least 10mm of alveolar bone height, without impinging on the maxillary sinus or inferior alveolar canal.
* Site has a dehiscence of the buccal or lingual bony plate of the tooth socket extending no more than 50% of the total depth of the socket.
* Female patients who have undergone a hysterectomy, tubal ligation, or menopause, and nonpregnant women of child-bearing potential.
* Patients are nonsmokers or former smokers. Current smokers may be included if they smoke \<10 cigarettes per day (less than or equal to 10 cigarettes per day)

Exclusion Criteria:

* Patient allergic to bovine-derived collagen products, Bacitracin, Gentamicin, Polymyxin
* Patients who will not cooperate with the follow-up schedule.
* Patients will not be entered who are mentally incompetent, prisoners, or pregnant.
* Pregnant women or women intending to become pregnant during the study period (as confirmed verbally; an over-the-counter pregnancy test will be provided if pregnancy status is unknown or suspected).

  * Patients who become pregnant during the study will be withdrawn and standard care will be delivered.
* Smokers who smoke \>10 cigarettes per day (more than 10 cigarettes per day)

Where it's running

• University of Texas Health Science Center at San Antonio School of Dentistry
  San Antonio, Texas, United States Recruiting

Study contacts

• Principal investigator: Brian Mealey, DDS, MS — The University of Texas Health Science Center at San Antonio
• Study coordinator: Brian Mealey, DDS, MS
• Email: mealey@uthscsa.edu
• Phone: 210-567-3589

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Curcumin topical spray for healing after a first molar extraction

  This study tests whether a curcumin spray applied to the extraction site helps healing and reduces pain compared with chlorhexidine spray or standard care in healthy adults undergoing a first molar extraction.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07874789

• Effect of four post-extraction socket approaches on preserving the ridge after tooth removal

  This study tests four ways to care for an extraction socket to see which best preserves the jawbone and gum after tooth removal for future implants.

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• Thymoquinone 0.2% Gel to Protect Bone After Tooth Extraction

  A gel with 0.2% thymoquinone is tested to see if it helps keep bone density and width after pulling a back upper tooth in adults.

  Recruiting Kafrelsheikh University · Kafr ash Shaykh, Kafrelsheikh · NCT07765745

• Beta-Tricalcium Phosphate for preserving the ridge after tooth extraction

  This early-phase trial tests whether beta-tricalcium phosphate helps preserve bone volume after tooth extraction compared with natural healing.

  Recruiting Early Phase 1 Egas Moniz - Cooperativa de Ensino Superior, CRL · Caparica, Monte Da Caparica · NCT07638319

• Ridge Preservation With Collagen Membrane After Tooth Extraction

  This study tests whether adding a resorbable collagen membrane to a bone graft improves jawbone preservation after tooth extraction for people who have significant buccal bone loss.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07580495

• Aromatherapy and computer-controlled local anesthesia to ease children's tooth extractions

  This study tests whether inhaled lavender and orange aromatherapy and a computer-controlled local anesthesia system reduce anxiety and pain for 6–12-year-olds having a lower primary molar removed.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07547371

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.