Nebulized tranexamic acid to stop post-tonsillectomy bleeding in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot gives three consecutive doses of nebulized tranexamic acid (TXA) to children who present with secondary post-tonsillectomy bleeding. Doses are weight-based: 500 mg per dose for children over 25 kg and 250 mg per dose for children under 25 kg, delivered via a standard nebulizer over roughly one hour. Treatments are administered in a clinical setting (emergency department or hospital) by trained staff, and patients are monitored for bleeding control and safety. The trial will record whether the mist stops bleeding without needing return to the operating room or blood transfusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Received a tonsillectomy
2. Presents to the ED with secondary\* post-tonsillectomy hemorrhage
3. Children between age of 2 to 17 years of age (i.e., before their 18th birthday) \*Secondary post-tonsillectomy hemorrhage is defined as greater than 24 hours from their primary tonsillectomy operation (arrival in recovery/PACU).

Exclusion Criteria:

1. Known and documented bleeding or clotting disorder.
2. Known pregnancy.
3. Patients with known hypersensitivity or allergic response to tranexamic acid.
4. Parents or guardians who cannot communicate in English or Spanish.
5. Intubation prior to enrollment.
6. Previously enrolled patients.

Where it's running

• University Hospital
  San Antonio, Texas, United States Recruiting

Study contacts

• Principal investigator: Andrew D Meyer, MD, MS — The University of Texas Health Science Center at San Antonio
• Study coordinator: Andrew D Meyer, MD, MS
• Email: meyera@uthscsa.edu
• Phone: 210-567-4424

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.