Effects of bariatric surgeries on glucose metabolism
Official title: The Effects of Bariatric Surgeries on Glucose Metabolism
Run by The University of Texas Health Science Center at San Antonio · NCT02823665 · Data updated 2026-11-12
This study tests how gastric bypass and sleeve gastrectomy surgeries affect blood sugar control after meals in people with diabetes to see which surgery might work better.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | The University of Texas Health Science Center at San Antonio Academic / other |
| Locations | 2 sites (San Antonio, Texas and 1 other locations) |
| Status | Recruiting |
| Started | July 2015 |
| Main results expected | August 2026 |
| Study ends | August 2027 |
| Registry record updated | September 9, 2025 |
| Trial ID | NCT02823665 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include hypoglycemic patients who have undergone gastric bypass surgery, asymptomatic individuals post-bariatric surgery, and healthy non-surgical individuals without a history of diabetes.
✕Probably not a fit
Patients with active serious medical conditions, type 2 diabetes, or a personal history of diabetes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how gastric bypass surgery and sleeve gastrectomy influence glucose metabolism through neural and hormonal factors after meals. It aims to assess the weight-independent effects of these surgeries on islet cell response and to compare the two surgical procedures. The findings could lead to new treatment strategies for diabetes and enhance the glycemic outcomes for patients experiencing partial diabetes remission or relapse following surgery.
Why it matters
Potential benefit: If successful, this study could provide insights that improve diabetes management and glycemic control in patients undergoing bariatric surgery.
How similar studies have gone: Other studies have shown promising results in understanding the metabolic effects of bariatric surgeries, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl * Asymptomatic individuals with bariatric surgery * Healthy non-surgical patients with no personal history of diabetes * Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center Exclusion Criteria: * Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies; * RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea. * Healthy non-surgical patients with personal history of diabetes For administration of atropine, the following exclusions also apply: * History of glaucoma * Uncontrolled hypertension (any subjects with BP\>140/90 and history of dyslipidemia * Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study) * Myasthenia gravis * Brain pathology * Enlarged prostate in men
Where it's running
-
Texas Diabetes Institute - University Health System
San Antonio, Texas, United States Recruiting -
South Texas Veterans Health Care System
San Antonio, Texas, United States Recruiting
Study contacts
- Principal investigator: Marzieh Salehi, MD, MS — The University of Texas Health Science Center at San Antonio
- Study coordinator: Marzieh Salehi, MD MS
- Email: salehi@uthscsa.edu
- Phone: 210-567-6691
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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15-year outcomes after sleeve gastrectomy in France
This study looks at how people who had sleeve gastrectomy have fared over 15 years to see long-term weight changes and health effects.
-
5-week combined aerobic and strength exercise after bariatric surgery
This test tries a 5-week combined aerobic and strength exercise program for adults recovering from sleeve gastrectomy or gastric bypass to see if it improves muscle quality, body composition, physical function, and quality of life.
-
Extra daily iron after sleeve gastrectomy to prevent anemia
This study tests whether taking an extra daily iron pill plus a multivitamin prevents iron deficiency anemia in adults during the six months after sleeve gastrectomy compared with taking a multivitamin alone.
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Foot reflexology to reduce nausea after sleeve gastrectomy
This will try foot reflexology to see if it reduces nausea and vomiting in adults after sleeve gastrectomy.
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Digestion and gut function after bariatric surgery
This project will test how digestion — including enzymes, bile acids, pH, and transit time — works in adults with obesity and in people at least one year after Roux‑en‑Y or sleeve gastrectomy by collecting intestinal samples and using a swallowable sensor capsule.
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Vestibular and balance changes before and after sleeve gastrectomy
This study will see if vestibular (balance) function improves in adults having sleeve gastrectomy for severe obesity by testing them before surgery and at one and six months after surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.