Sponsor or institution
Clinical trials and research at State University New York Stony Brook
As of November 12, 2026, Find a Trial lists 390 NIH-funded research projects at this institution, with $173.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 390NIH research projects
NIH-funded research (newest 40 of 390)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding how oral microbes interact at the single-cell level
Aimed at uncovering how bacteria in the mouth stick together and influence each other, using advanced imaging to reveal functional connections at the microscopic level.
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Cellular and circuit-level mechanisms of HIV/NRTI-related pain in the context of opioids
This NIH grant explores how HIV medicines (NRTIs) and opioids may combine to cause chronic pain, aiming to help people living with HIV who experience pain.
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Using a dye to see how kidneys work and how transporters act
A new, simple dye-based test could help doctors measure kidney tubular function and transporter activity more accurately in people with acute kidney problems.
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Interneuronal aging in trauma-exposed World Trade Center responders
A study in WTC responders with PTSD will look at brain interneuron health using advanced imaging and proteins to understand how PTSD may affect aging brains.
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Dynamic PTSD-Related Cognitive Risk in Aging WTC Responders
This project follows World Trade Center responders as they age to understand how PTSD symptoms relate to changes in thinking skills over time.
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How CHIKV viruses adapt to mosquitoes and cause disease in people
This project explores how the chikungunya virus changes to become better at infecting mosquitoes and causing disease in humans, with the goal of understanding how to prevent transmission and illness.
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Alphavirus infections and tiny blood vessels: what makes CHIKV struggle or spread
Scientists are studying how alphaviruses infect tiny blood vessels and how that affects disease, focusing on human heart-related microvascular cells to find new ways to block infection.
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Fatty acid signals that control protein production during fasting and aging
This grant explores how fasting changes the way cells produce proteins to slow aging and improve insulin sensitivity, with a focus on type 2 diabetes risk.
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BrainAnalyzIR: a user-friendly software to improve brain signal analysis with fNIRS
A software tool called Brain AnalyzIR helps researchers get more accurate results from a non-invasive brain scan method (fNIRS) by addressing data noise and motion artifacts.
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How the aging lens affects vision and what we can do about it
This grant studies how aging changes lens water and ion balance to cause cataracts and presbyopia, with the goal of better preserving vision for aging adults.
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Virus-OR Olfactory System Links to Alzheimer’s Disease Progression
This grant explores how common viruses in the nose might speed up Alzheimer’s disease and what that could mean for prevention or treatment.
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Adversities and resilience in young adults: a long-term study in Malawi and its effects on health and families
This grant funds a long-term study of how difficult childhood experiences affect health, relationships, and parenting in young adults in Malawi and how these effects may pass to the next generation.
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Gasdermin D's role in the bone marrow and age-related abnormal blood cell growth
This project tests whether lowering a protein called Gasdermin D in bone marrow support cells can slow clonal hematopoiesis, an age-related condition that raises leukemia risk.
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Chibby proteins' role in sperm development and male fertility
This project looks at how Chibby family proteins help sperm form and whether problems with these proteins contribute to male infertility.
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Preventing invasive prostate cancer with a targeted motility blocker
A new approach uses a precision drug called KBU2046 to block how prostate cancer cells move, with the aim of stopping cancer from becoming invasive.
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Prefrontal pathway-related protein production in emotional memories
This NIH grant explores how brain pathways control protein building blocks during the formation of emotional memories, with the goal of understanding PTSD better.
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Understanding how aggressive cell states emerge in castration-resistant prostate cancer
A research project aims to uncover the hidden cell states that help prostate cancer resist standard therapy and how these states arise early in tumor development.
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TDP-43 protein changes and reactivated retroviruses in Alzheimer’s and related dementias
Researchers are looking at whether abnormal TDP-43 protein and reawakened retroviruses damage brain cells and contribute to Alzheimer’s and related dementias.
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Epigenetic Basis for Controlling Aggressive IDH-Mutant Gliomas
Aims to understand and shape the epigenetic changes in IDH-mutant brain tumors to restrain their growth, which could lead to new, targeted treatment options for patients.
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Role of CCR2+ immune cells in persistent Salmonella granulomas
A patient-facing summary of how a study will look at how specific immune cells help form and control granulomas in chronic Salmonella infections.
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mRNA splicing in podocyte biology and glomerular disease
Aimed at understanding how RNA splicing in kidney cells called podocytes affects glomerular disease, with the goal of finding new diagnostic and treatment approaches for kidney failure.
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Finding ways to block kidney cysts by targeting a key RNA in ADPKD
A researcher is studying a long noncoding RNA called Hoxb3os to see if it can be targeted to slow or stop cyst growth in autosomal dominant polycystic kidney disease (ADPKD).
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How the TET1 gene affects non-alcoholic fatty liver disease
Researchers are looking at whether changes in the TET1 gene and DNA 'tagging' (methylation) play a role in adult non-alcoholic fatty liver disease.
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Noninvasive imaging of brain CSF waves using AI-powered MRI tagging
A noninvasive MRI approach using fast tagging and AI-based pattern recognition to measure tiny CSF pulsations in people, which may relate to brain waste clearance.
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Neuroinflammation as a Target to Protect Thinking in Heart Failure Patients
A small feasibility study will test whether a brain scan can show that a heart-failure treatment reduces brain inflammation and protects thinking skills in people with heart failure and cognitive concerns.
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Foundations for next-generation intrapartum decision support using smart, real-time fetal monitoring
A new method will combine advanced statistical models to give real-time, trusted estimates of fetal well-being during labor for use by clinicians and families.
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Environmental contaminant 1,4-dioxane and cancer: how it may spur tumor progression through cell communication
A NIH grant is studying how exposure to the environmental toxin 1,4-dioxane could promote cancer by altering cell signals and small particles that influence cancer spread.
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Repairing TMZ-caused DNA damage in glioblastoma cells
A scientist team will study how temozolomide damages DNA in brain cancer cells and how the cells repair that damage, which may reveal new ways to overcome drug resistance.
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Future of Families Sleep Health in Young Adults and Digital Media
A study will track sleep, digital media use, and wellbeing in young adults using wearables and a smartphone app to understand how everyday behaviors relate to health over time.
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Trait-Based Metagenomics to Understand Microbiome Dynamics in Cancer Care
A cancer-focused grant is funding new software and methods to understand how complex gut microbiomes behave and affect treatment outcomes.
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Caring for someone with dementia and its effects on your thinking and daily function
This project follows older caregivers of people with Alzheimer’s and related dementias to see how caregiving affects their thinking, memory, and physical health over time.
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TET1, Sex Differences, and Alcohol-Linked Liver Cancer
This grant looks at how a gene called TET1 and sex differences affect the risk of liver cancer in people who drink alcohol.
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Resilience training to support first responders' mental health
A large trial will test a 4-hour resilience workshop designed to help first responders cope with trauma and reduce PTSD and depression symptoms.
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Proteoglycans signaling to hair follicles to drive growth and renewal
A portion of hair growth may be boosted by how dermal cells’ proteoglycans tell hair follicle cells to grow and renew.
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RPE metabolism and scarring in the back of the eye
A study tests whether blocking a glycolysis enzyme in retinal pigment epithelium cells can prevent scar tissue from forming after abnormal eye blood vessel growth, potentially protecting vision for people with age-related macular degeneration.
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Urine cadmium and bone health in older adults
This project looks at whether long-term cadmium exposure, measured in urine, is linked to bone loss and fractures in older adults.
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Lens Aquaporins and GPX1: How oxygen balance during aging affects cataract risk
Researchers are studying how eye lens water channels and an antioxidant enzyme influence hydrogen peroxide balance to help prevent aging-related cataracts.
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Bioprinted vascular grafts to help children and adults with single-ventricle heart defects
A new bioprinting approach aims to create patient-specific, tissue-like vascular conduits that can repair damaged heart vessels and improve blood flow for people with single-ventricle defects.
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Targeting pancreatic cancer aging with immune-based PET imaging
A study to use an antibody-based PET imaging approach to detect senescent cells in pancreatic cancer to guide future therapies.
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Adversities and resilience in young adults in Sub‑Saharan Africa and their children
This grant studies how childhood adversity shapes health, relationships, and parenting in young adults in Malawi and how these effects may spread to the next generation.
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