Targeting pancreatic cancer aging with immune-based PET imaging
Official title: Targeting Pancreatic Cancer Senescence with ImmunoPET
Funded at State University New York Stony Brook · NIH-11408800 · Data updated 2026-11-12
A study to use an antibody-based PET imaging approach to detect senescent cells in pancreatic cancer to guide future therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | May 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $190,136 |
| NIH project number | 5R00CA276804-04 |
| Project ID | NIH-11408800 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with pancreatic cancer who are eligible for imaging studies and may benefit from future senescence-targeted therapies.
✕Less likely to help
Patients with cancers outside the pancreas or those who cannot undergo PET imaging may not benefit.
What this research studies
This project aims to visualize senescent cells in pancreatic tumors using a specialized antibody-based PET imaging agent, offering a noninvasive way to map where aging cells are in the cancer. By pairing senescence-targeted imaging with existing treatments, researchers hope to improve how we tailor therapies for pancreatic cancer patients. The work builds on prior findings that senescent cells influence tumor biology and may respond to targeted treatment strategies. If successful, this could pave the way for imaging-guided interventions that potentially enhance outcomes for people affected by pancreatic cancer.
Why it matters
Potential benefit: If the imaging approach works, patients could receive more precisely targeted treatments and closer monitoring based on senescence patterns in their tumors.
How similar studies have gone: Antibody-based imaging for tumor biology is an area with growing evidence, though applying it specifically to senescence in pancreatic cancer is emerging.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Pratt, Edwin Charles — State University New York Stony Brook
- Study coordinator: Pratt, Edwin Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.