mRNA splicing in podocyte biology and glomerular disease
Funded at State University New York Stony Brook · NIH-11448573 · Data updated 2026-11-12
Aimed at understanding how RNA splicing in kidney cells called podocytes affects glomerular disease, with the goal of finding new diagnostic and treatment approaches for kidney failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | September 21, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $755,725 |
| NIH project number | 1R01DK145542-01A1 |
| Project ID | NIH-11448573 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with glomerular disease or kidney injury may benefit from future diagnostics or therapies developed from this research.
✕Less likely to help
There may be no direct benefit for healthy individuals or those without kidney disease.
What this research studies
This project studies how alternative RNA splicing in podocytes changes the filtration barrier of the kidney and contributes to glomerular disease. Researchers will map splicing events, identify regulatory proteins and microRNAs, and test new targeted nanoparticle methods to deliver RNA-based therapies. The work uses cultured podocytes, organoids, rodent models, and human data to connect splicing patterns to disease.
Why it matters
Potential benefit: If successful, it could lead to new RNA-based diagnostics and targeted treatments for glomerular diseases that threaten kidney function.
How similar studies have gone: Prior work has begun to link podocyte biology and RNA splicing to kidney disease, with promising preclinical findings.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Agrawal, Shipra — State University New York Stony Brook
- Study coordinator: Agrawal, Shipra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.