Role of CCR2+ immune cells in persistent Salmonella granulomas
Official title: Role of inflammatory monocytes and other CCR2+ cells in the granulomatous response to persistent Salmonella infection
Funded at State University New York Stony Brook · NIH-11449303 · Data updated 2026-11-12
A patient-facing summary of how a study will look at how specific immune cells help form and control granulomas in chronic Salmonella infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | July 31, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $722,227 |
| NIH project number | 1R01AI192792-01A1 |
| Project ID | NIH-11449303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with chronic Salmonella infection or related granulomatous conditions in which CCR2+ immune cells are likely involved.
✕Less likely to help
People without persistent granulomatous infections or without CCR2+ cell involvement may not directly benefit.
What this research studies
This project studies how inflammatory monocytes and other CCR2+ immune cells contribute to the formation and maintenance of granulomas during long-lasting Salmonella infections. Researchers will study these cells in living systems to understand how they organize immune responses and antimicrobial activity within granulomas. The goal is to uncover mechanisms that balance protection against infection with potential tissue damage, which could guide new therapies for granulomatous diseases. The work may involve animal models and techniques that examine immune cell behavior in real time to link cellular actions to granuloma structure and function.
Why it matters
Potential benefit: If successful, the findings could lead to new approaches to treat chronic granulomatous infections and related inflammatory diseases.
How similar studies have gone: Similar studies have shown that CCR2+ cells influence granuloma dynamics in infections, though the exact mechanisms are still being defined.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Van Der Velden, Adrianus Wilhelmus Maria — State University New York Stony Brook
- Study coordinator: Van Der Velden, Adrianus Wilhelmus Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.