TET1, Sex Differences, and Alcohol-Linked Liver Cancer
Official title: TET1 and Sex Differences in Alcohol Associated Liver Tumorigenesis
Funded at State University New York Stony Brook · NIH-11424652 · Data updated 2026-11-12
This grant looks at how a gene called TET1 and sex differences affect the risk of liver cancer in people who drink alcohol.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | May 1, 2026 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $485,384 |
| NIH project number | 7R01AA031497-02 |
| Project ID | NIH-11424652 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with heavy alcohol use or alcohol-related liver disease, and researchers studying liver cancer risk.
✕Less likely to help
People without alcohol exposure or liver disease are unlikely to directly benefit.
What this research studies
Researchers will study why men and women respond differently to heavy alcohol use in the development of liver cancer, focusing on DNA methylation processes governed by TET1. They will use animal models and molecular analyses to see how TET1 loss changes liver biology in males and females during chronic alcohol exposure. Findings could reveal why women might have a higher cancer risk with heavy drinking and point to new targets for prevention or treatment. The work aims to connect sex-specific biology, alcohol effects, and liver cancer risk in a way that could inform future human studies.
Why it matters
Potential benefit: Understanding the mechanisms could lead to sex-specific prevention strategies and new approaches to reduce liver cancer risk in people who drink heavily.
How similar studies have gone: Previous work shows sex differences and TET1 involvement in liver biology; this study builds on those findings in a disease-relevant model.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Huang, Chiung-Kuei — State University New York Stony Brook
- Study coordinator: Huang, Chiung-Kuei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.