Preventing invasive prostate cancer with a targeted motility blocker
Official title: Preventing invasive prostate cancer
Funded at State University New York Stony Brook · NIH-11471847 · Data updated 2026-11-12
A new approach uses a precision drug called KBU2046 to block how prostate cancer cells move, with the aim of stopping cancer from becoming invasive.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | September 19, 2023 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,497,888 |
| NIH project number | 7R01CA276846-04 |
| Project ID | NIH-11471847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are men at risk of prostate cancer progression where a preventive intervention could be applicable, pending further clinical development.
✕Less likely to help
Patients without a risk of developing invasive prostate cancer or those who are not eligible for future trial contexts may not benefit.
What this research studies
This grant explores how a first-in-class agent, KBU2046, can selectively reduce tumor cell movement to prevent prostate cancer from becoming invasive. Researchers will map exactly where KBU2046 binds in cells and how it changes signaling pathways that control motility, using computer models, biochemical tests, and advanced protein techniques. The work includes developing tools to study the drug in living cells and to understand how it affects cancer progression, with the goal of offering a preventive option for patients at risk of invasive disease. By testing in clinically relevant models, the project seeks to establish a pathway from discovery to potential early intervention in humans.
Why it matters
Potential benefit: If successful, this project could lead to a new preventive therapy that blocks cancer spread at its early stages.
How similar studies have gone: There is prior evidence that targeting cell movement can influence cancer progression, but this specific inhibitor and its mechanism are novel.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Bergan, Raymond C. — State University New York Stony Brook
- Study coordinator: Bergan, Raymond C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.