Finding ways to block kidney cysts by targeting a key RNA in ADPKD
Official title: Identifying the Therapeutic Potential and Molecular Mechanism of lnc-Hoxb3os in ADPKD
Funded at State University New York Stony Brook · NIH-11447262 · Data updated 2026-11-12
A researcher is studying a long noncoding RNA called Hoxb3os to see if it can be targeted to slow or stop cyst growth in autosomal dominant polycystic kidney disease (ADPKD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | August 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $785,689 |
| NIH project number | 1R01DK143971-01A1 |
| Project ID | NIH-11447262 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for ADPKD who may benefit from future RNA-targeted therapies and contribute samples or data.
✕Less likely to help
Patients without access to any RNA-targeted therapies or those not eligible for future trials may not see direct benefit.
What this research studies
This project focuses on how a specific long noncoding RNA, Hoxb3os, may influence cyst formation in ADPKD. By using mouse models and human kidney cells, the team aims to uncover how this RNA affects disease pathways and test potential ways to counteract harmful effects. The work seeks to identify new RNA-level targets that could lead to future therapies to slow kidney damage in people with ADPKD.
Why it matters
Potential benefit: If successful, the research could pave the way for new treatments that slow cyst growth and protect kidney function in ADPKD patients.
How similar studies have gone: Previous work showed that modulating Hoxb3os in mice affected cyst development, suggesting potential for human relevance in ADPKD.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Aboudehen, Karam — State University New York Stony Brook
- Study coordinator: Aboudehen, Karam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.