Sponsor or institution
Clinical trials and research at St. Louis VA Medical Center
As of November 12, 2026, Find a Trial lists 26 NIH-funded research projects at this institution. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 26NIH research projects
NIH-funded research (26)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Epigenetic clues in a kidney disease model linked to FSGS
A study exploring how epigenetic changes influence a common kidney disease (FSGS) using a new model to understand why it happens and how it might be prevented.
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A close look at aging (senescent) cells in ALS brain and spinal cord
Researchers will map aged (senescent) cells in brain and spinal cord tissue from people with ALS to learn how those cells might drive disease progression.
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Remote kidney injury triggers and lung inflammation in AKI patients
Researchers are studying how acute kidney injury in patients, especially veterans, leads to lung problems and respiratory failure, with focus on the kidney-to-lung communication and potential targets.
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Molecular clues about how enterotoxigenic E. coli causes diarrhea
This project looks at how a nasty gut bacterium (ETEC) causes diarrhea and how human gut cells respond, with the aim of understanding why infections happen and persist.
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Comparing newer versus older diabetes medicines for heart and kidney health
This project compares newer diabetes medicines (SGLT2 inhibitors and GLP‑1 drugs) with older options to see which are safer and more helpful for adults with type 2 diabetes.
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Vitamin D and early-life risk of obesity and insulin resistance
This project tests whether giving vitamin D during pregnancy helps prevent children from becoming obese or insulin-resistant.
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How damaged kidney tubule cells use fatty acids
This project tests whether changing how kidney tubule cells burn fats can prevent or reduce sudden kidney injury in people at risk, like those having heart bypass surgery.
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Mapping toxic aging (senescent) cells in ALS brain and spinal cord
This project looks for stressed 'senescent' cells in brain and spinal cord tissue from people with ALS to learn how they might drive nerve damage.
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Heart and immune cell cleanup of damaged mitochondria after heart attack
This project looks at how heart muscle and immune cells clear damaged mitochondria after a heart attack to help people with ischemic heart failure.
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Mitochondria-targeted treatments for uromodulin-related chronic kidney disease
This project aims to fix mitochondria in kidney cells to slow or stop kidney damage in adults with uromodulin-related chronic kidney disease.
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Understanding how B lymphocytes contribute to autoimmune diseases like rheumatoid arthritis
This study is looking at how certain immune cells called B lymphocytes might contribute to rheumatoid arthritis by producing harmful antibodies, and it’s exploring how a protein called BTK affects this process, which could help us understand more about the disease and find better ways to manage it.
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Investigating the role of vitamin D in obesity and insulin resistance in young veterans
This study is looking at how not getting enough vitamin D during pregnancy might lead to weight gain and health problems in young veterans and their children, and it hopes to find out if taking vitamin D supplements while pregnant can help prevent these issues.
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Investigating how natural killer cell-derived vesicles can kill multiple myeloma cells
This study is looking at how tiny particles from special immune cells can help fight multiple myeloma, especially in patients who have been affected by harmful substances like Agent Orange, with the hope of finding new ways to treat this cancer while protecting healthy cells.
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Understanding how immune cells move in heart transplants
This study is looking at how immune cells move in heart transplants and how they might cause problems like tissue damage and rejection, with the hope of finding ways to help patients have better outcomes after their heart surgery.
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Investigating how fatty acid oxidation affects injured kidney tubules
This study is looking at how certain fats in the body affect kidney healing in veterans who are more likely to have kidney problems, especially after heart surgery, and it hopes to find new ways to help protect their kidneys using a medication that's already approved for use.
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Understanding how dengue vaccines and infections create lasting immunity
This study is looking at how well the TDV/TAK003 dengue vaccine helps your immune system fight off dengue compared to getting the virus naturally, especially for people who haven't been infected before, and it will track your immune response and health over the years to see how long that protection lasts.
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Investigating how vitamin D deficiency affects blood pressure through immune cells
This study is looking at how low vitamin D levels might lead to high blood pressure by affecting certain immune cells, and it's especially aimed at helping veterans who often have vitamin D deficiency.
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Measuring brain inflammation in Parkinson's disease using advanced MRI techniques
This study is looking at a new MRI method to see how inflammation in the brain affects veterans with Parkinson's disease, which could help doctors track the disease better and find ways to slow it down.
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Targeting a specific pathway in head and neck cancer treatment
This study is looking at how a specific pathway in our cells might affect the growth and treatment resistance of advanced head and neck cancer, with the hope of finding new ways to improve treatments for patients like you.
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Investigating how immune cells communicate in heart disease
This study is looking at how immune cells, especially a type called macrophages, interact with heart cells after a heart attack to find new ways to help the heart heal and work better.
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Investigating the role of immune cells in the brain related to neurological diseases
This study is looking at how certain brain immune cells act in people with multiple sclerosis and ALS by examining their spinal fluid, hoping to find clues that could help us understand these conditions better.
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Investigating the genetic and environmental factors in kidney scarring
This study is looking into how both genes and early life experiences can affect kidney health in people with focal segmental glomerulosclerosis (FSGS), especially in African Americans, to help find better ways to treat or prevent this condition.
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Targeting mitochondria to treat chronic kidney disease linked to uromodulin mutations
This study is looking at a type of kidney disease caused by certain gene changes, and it's using special technology to create mice that have the same issues as people with this condition, so researchers can learn more about how it harms the kidneys and find new ways to help, especially for veterans who might be more af
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Comparing the effectiveness and safety of newer and older diabetes medications
This study looks at how different diabetes medications, both new and old, impact heart and kidney health, helping doctors understand which options might be better for patients like you.
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Using targeted nanotherapy to prevent post-traumatic osteoarthritis after joint injuries
This study is looking at a new treatment using tiny particles to help prevent arthritis in people who have hurt their knees, especially those with ACL injuries, so they can keep their joints healthier and avoid needing surgery later on.
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Investigating how kidney injury affects lung health
This study is looking at how kidney problems can affect the lungs and aims to find out what happens in the body during this process, so we can discover new ways to help patients who experience lung issues after kidney injury.
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