Remote kidney injury triggers and lung inflammation in AKI patients
Official title: Remote injury responses after AKI
Funded at St. Louis VA Medical Center · NIH-11412990 · Data updated 2026-11-12
Researchers are studying how acute kidney injury in patients, especially veterans, leads to lung problems and respiratory failure, with focus on the kidney-to-lung communication and potential targets.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Louis VA Medical Center NIH-funded |
| Lab location | 1 site (St. Louis, UNITED STATES) |
| Project start | July 1, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| NIH project number | 2I01RD001486-05A2 |
| Project ID | NIH-11412990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute kidney injury or acute kidney failure, particularly in ICU settings, who may develop or have respiratory complications.
✕Less likely to help
Patients without AKI or acute kidney issues or those not experiencing related lung inflammation are unlikely to benefit.
What this research studies
This project looks at how kidney injury can cause remote inflammation in the lungs and worsen breathing in ICU patients. It highlights a potential key mediator, osteopontin, released after AKI, and how neutrophils in the lungs contribute to hypoxemia. The study aims to uncover the signaling pathways and receptors involved to identify new therapeutic targets. It aligns with patients who have acute kidney failure and may develop severe lung complications.
Why it matters
Potential benefit: If successful, this research could reveal targets to reduce lung inflammation and improve oxygenation in AKI patients, potentially lowering mortality.
How similar studies have gone: Previous work has linked kidney injury to distant organ inflammation and identified osteopontin as a mediator, supporting further exploration.
Where this research is happening
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St. Louis VA Medical Center
St. Louis, United States Active
Researchers
- Principal investigator: Herrlich, Andreas — St. Louis VA Medical Center
- Study coordinator: Herrlich, Andreas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.