Investigating the genetic and environmental factors in kidney scarring
Epigenetic mechanisms in a novel model of FSGS
This study is looking into how both genes and early life experiences can affect kidney health in people with focal segmental glomerulosclerosis (FSGS), especially in African Americans, to help find better ways to treat or prevent this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Louis VA Medical Center NIH-funded |
| Lab location | 1 site (St. Louis, UNITED STATES) |
| Project ID | NIH-10924486 on NIH RePORTER |
What this research studies
This research focuses on understanding focal segmental glomerulosclerosis (FSGS), a condition characterized by scarring in the kidneys. It aims to explore how genetic and environmental factors contribute to this disease, particularly in African American populations who are disproportionately affected. The study will examine the role of developmental programming, which refers to how early life conditions can influence kidney health later in life. By identifying the molecular mechanisms involved, the research seeks to pave the way for new therapeutic approaches to treat or prevent FSGS.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American individuals with a history of kidney issues or those at risk for developing FSGS.
Not a fit: Patients with FSGS who do not belong to the targeted demographic or those with well-defined causes of their kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for kidney scarring and better health outcomes for patients at risk of kidney disease.
How similar studies have performed: Previous research has shown promise in understanding the genetic and environmental factors affecting kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
St. Louis, UNITED STATES
- St. Louis VA Medical Center — St. Louis, United States (Active)
Researchers
- Principal investigator: Rauchman, Michael I — St. Louis VA Medical Center
- Study coordinator: Rauchman, Michael I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.