Investigating how immune cells communicate in heart disease
Mitophagy pathways in cellular cross-talk in the myocardium
['FUNDING_OTHER'] · ST. LOUIS VA MEDICAL CENTER · NIH-10950329
This study is looking at how immune cells, especially a type called macrophages, interact with heart cells after a heart attack to find new ways to help the heart heal and work better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. LOUIS VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (St. Louis, UNITED STATES) |
| Trial ID | NIH-10950329 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the interactions between immune cells and heart cells in the context of heart disease, particularly after a heart attack. It aims to explore how these immune cells influence heart cell function and structure, especially during the inflammatory response that follows injury. By studying the role of macrophages, a type of immune cell, the research seeks to identify potential therapeutic strategies that could improve heart health and recovery. The approach includes examining the mechanisms of cell communication and the impact of inflammation on heart function.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced a myocardial infarction or have ischemic cardiomyopathy.
Not a fit: Patients with non-cardiac related health issues or those who have not experienced heart-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and heart function in patients with heart disease.
How similar studies have performed: Previous studies have shown promising results in understanding immune cell roles in heart disease, indicating that this research builds on established findings.
Where this research is happening
St. Louis, UNITED STATES
- ST. LOUIS VA MEDICAL CENTER — St. Louis, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIWAN, ABHINAV — ST. LOUIS VA MEDICAL CENTER
- Study coordinator: DIWAN, ABHINAV
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.