Investigating how immune cells communicate in heart disease
Official title: Mitophagy pathways in cellular cross-talk in the myocardium
Funded at St. Louis VA Medical Center · NIH-10950329 · Data updated 2026-11-12
This study is looking at how immune cells, especially a type called macrophages, interact with heart cells after a heart attack to find new ways to help the heart heal and work better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Louis VA Medical Center NIH-funded |
| Lab location | 1 site (St. Louis, UNITED STATES) |
| Project start | October 1, 2022 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005981-03 |
| Project ID | NIH-10950329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have experienced a myocardial infarction or have ischemic cardiomyopathy.
✕Less likely to help
Patients with non-cardiac related health issues or those who have not experienced heart-related conditions may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between immune cells and heart cells in the context of heart disease, particularly after a heart attack. It aims to explore how these immune cells influence heart cell function and structure, especially during the inflammatory response that follows injury. By studying the role of macrophages, a type of immune cell, the research seeks to identify potential therapeutic strategies that could improve heart health and recovery. The approach includes examining the mechanisms of cell communication and the impact of inflammation on heart function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and heart function in patients with heart disease.
How similar studies have gone: Previous studies have shown promising results in understanding immune cell roles in heart disease, indicating that this research builds on established findings.
Where this research is happening
-
St. Louis VA Medical Center
St. Louis, United States Active
Researchers
- Principal investigator: Diwan, Abhinav — St. Louis VA Medical Center
- Study coordinator: Diwan, Abhinav
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.