Targeting mitochondria to treat chronic kidney disease linked to uromodulin mutations
Official title: Therapeutic Targeting of Mitochondria in Uromodulin-Associated Chronic Kidney Disease
Funded at St. Louis VA Medical Center · NIH-10923602 · Data updated 2026-11-12
This study is looking at a type of kidney disease caused by certain gene changes, and it's using special technology to create mice that have the same issues as people with this condition, so researchers can learn more about how it harms the kidneys and find new ways to help, especially for veterans who might be more affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Louis VA Medical Center NIH-funded |
| Lab location | 1 site (St. Louis, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01BX006401-01A1 |
| Project ID | NIH-10923602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with a diagnosis of uromodulin-associated chronic kidney disease or those with genetic variants linked to this condition.
✕Less likely to help
Patients with chronic kidney disease not related to uromodulin mutations are unlikely to benefit from this research.
What this research studies
This research focuses on chronic kidney disease associated with uromodulin mutations, which leads to progressive kidney damage. The team is using advanced CRISPR technology to create a mouse model that mimics the most common human mutation, allowing them to study the disease's mechanisms. By investigating how mitochondrial dysfunction contributes to kidney cell death, the researchers aim to identify potential therapeutic targets that could improve kidney health. This work is particularly relevant for understanding the disease in veterans, who may be disproportionately affected.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that significantly improve kidney function and quality of life for patients with uromodulin-associated chronic kidney disease.
How similar studies have gone: While the approach using CRISPR technology is innovative, similar research targeting mitochondrial dysfunction in kidney diseases has shown promise, indicating potential for success.
Where this research is happening
-
St. Louis VA Medical Center
St. Louis, United States Active
Researchers
- Principal investigator: Chen, Ying Maggie — St. Louis VA Medical Center
- Study coordinator: Chen, Ying Maggie
Related research
Other NIH-funded projects on the same topics.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
-
Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
-
Boosting self-care and physical activity for older adults with chronic kidney disease
This program helps older adults with chronic kidney disease build the skills, confidence, and motivation to be more physically active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.