Understanding how immune cells move in heart transplants
Leukocyte trafficking in thoracic grafts
This study is looking at how immune cells move in heart transplants and how they might cause problems like tissue damage and rejection, with the hope of finding ways to help patients have better outcomes after their heart surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Louis VA Medical Center NIH-funded |
| Lab location | 1 site (St. Louis, UNITED STATES) |
| Project ID | NIH-11098503 on NIH RePORTER |
What this research studies
This research investigates the movement of immune cells in heart transplants, particularly focusing on how these cells contribute to tissue damage and graft rejection. Using advanced imaging techniques, the study aims to visualize the infiltration of leukocytes into transplanted hearts in real time. By identifying the cellular and molecular signals that regulate this process, the research seeks to develop strategies to mitigate the immune response that leads to graft dysfunction. The ultimate goal is to improve outcomes for patients undergoing heart transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing heart transplantation, particularly those at risk for primary graft dysfunction.
Not a fit: Patients who are not candidates for heart transplantation or those with non-cardiovascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the success rates of heart transplants by reducing immune-related complications.
How similar studies have performed: Previous research has shown promise in understanding immune responses in transplant settings, suggesting that this approach could yield valuable insights.
Where this research is happening
St. Louis, UNITED STATES
- St. Louis VA Medical Center — St. Louis, United States (Active)
Researchers
- Principal investigator: Kreisel, Daniel — St. Louis VA Medical Center
- Study coordinator: Kreisel, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.