Comparing the effectiveness and safety of newer and older diabetes medications
Official title: Comparative Effectiveness and Safety of Newer and Older Antihyperglycemic Medications
Funded at St. Louis VA Medical Center · NIH-10920416 · Data updated 2026-11-12
This study looks at how different diabetes medications, both new and old, impact heart and kidney health, helping doctors understand which options might be better for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Louis VA Medical Center NIH-funded |
| Lab location | 1 site (St. Louis, UNITED STATES) |
| Project start | July 1, 2021 |
| Project end | December 31, 2026 |
| Funding year | 2024 |
| NIH project number | 5I01HX003252-04 |
| Project ID | NIH-10920416 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with diabetes who are considering or currently using antihyperglycemic medications.
✕Less likely to help
Patients who are not diagnosed with diabetes or those who are not on antihyperglycemic medications may not benefit from this research.
What this research studies
This research investigates how different antihyperglycemic medications, both newer and older, affect patients with diabetes, particularly focusing on their cardiovascular and kidney health. It aims to determine whether newer medications, like SGLT2 inhibitors and GLP-1 receptor agonists, provide better outcomes compared to older, less expensive options. By analyzing real-world data, the study will assess the benefits and risks associated with these medications based on patients' cardiovascular risk and kidney function. The findings will help guide healthcare providers in making informed decisions about diabetes treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for diabetes, enhancing patient outcomes related to cardiovascular and kidney health.
How similar studies have gone: Previous research has shown promising results with newer antihyperglycemic agents, indicating potential benefits, but this specific comparative effectiveness approach is relatively novel.
Where this research is happening
-
St. Louis VA Medical Center
St. Louis, United States Active
Researchers
- Principal investigator: Al-Aly, Ziyad — St. Louis VA Medical Center
- Study coordinator: Al-Aly, Ziyad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.