Epigenetic clues in a kidney disease model linked to FSGS
Official title: Epigenetic mechanisms in a novel model of FSGS
Funded at St. Louis VA Medical Center · NIH-11602680 · Data updated 2026-11-12
A study exploring how epigenetic changes influence a common kidney disease (FSGS) using a new model to understand why it happens and how it might be prevented.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Louis VA Medical Center NIH-funded |
| Lab location | 1 site (St. Louis, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| NIH project number | 5I01BX005944-03 |
| Project ID | NIH-11602680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults, including African American individuals, with or at risk for FSGS or related kidney conditions.
✕Less likely to help
Healthy individuals without kidney disease are unlikely to benefit directly.
What this research studies
This project looks at how gene regulation changes may contribute to FSGS, especially in African American adults who are at higher risk. Researchers will use a novel model to study epigenetic mechanisms and how early-life factors like birth weight and growth affect kidney health later in life. The aim is to uncover molecular pathways that could become targets for therapies to prevent or slow kidney damage.
Why it matters
Potential benefit: If successful, findings could point to new ways to prevent or treat FSGS and reduce progression to kidney failure.
How similar studies have gone: Similar research supports a role for epigenetic regulation in kidney disease, but a novel model could provide deeper insights.
Where this research is happening
-
St. Louis VA Medical Center
St. Louis, United States Active
Researchers
- Principal investigator: Rauchman, Michael I — St. Louis VA Medical Center
- Study coordinator: Rauchman, Michael I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.