Measuring brain inflammation in Parkinson's disease using advanced MRI techniques
Diffusion Basis Spectrum Imaging for Measurement of Neuroinflammation in Parkinson Disease
['FUNDING_OTHER'] · ST. LOUIS VA MEDICAL CENTER · NIH-10980522
This study is looking at a new MRI method to see how inflammation in the brain affects veterans with Parkinson's disease, which could help doctors track the disease better and find ways to slow it down.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. LOUIS VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (St. Louis, UNITED STATES) |
| Trial ID | NIH-10980522 on ClinicalTrials.gov |
What this research studies
This research focuses on Parkinson's disease, a neurodegenerative condition that affects many veterans, leading to both motor and cognitive symptoms. The study aims to develop a new MRI technique called Diffusion Basis Spectrum Imaging (DBSI) to measure neuroinflammation in the brains of individuals with Parkinson's. By comparing DBSI results with established imaging and tissue analysis methods, the research seeks to validate this technique as a reliable biomarker for tracking disease progression. This could help in developing therapies that slow down the progression of Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Parkinson's disease, particularly veterans who are affected by this condition.
Not a fit: Patients with other neurodegenerative diseases or those without a diagnosis of Parkinson's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for monitoring Parkinson's disease progression and developing targeted therapies.
How similar studies have performed: Previous research has successfully utilized similar imaging techniques in other neurodegenerative diseases, indicating potential for success in this novel application.
Where this research is happening
St. Louis, UNITED STATES
- ST. LOUIS VA MEDICAL CENTER — St. Louis, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHITE, ROBERT L — ST. LOUIS VA MEDICAL CENTER
- Study coordinator: WHITE, ROBERT L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated neurodegenerative disease, age associated neurodegenerative disorder, age dependent neurodegenerative disease, age dependent neurodegenerative disorder