Sponsor or institution
Clinical trials and research at Sloan-Kettering Inst Can Research
As of November 12, 2026, Find a Trial lists 849 NIH-funded research projects at this institution, with $537.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 849NIH research projects
NIH-funded research (newest 40 of 849)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understand how skeletal muscle nuclei specialize and arrange themselves for proper muscle function
A study to uncover how the hundreds of nuclei in skeletal muscle fibers acquire different roles and positions to keep muscles strong and healthy.
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Genomic profiling and outcomes of cancers in World Trade Center-exposed survivors and responders
This project looks at the genetic makeup and real-world cancer outcomes in people exposed to the World Trade Center disaster to understand how their cancers behave and respond to treatments.
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Meaning-Centered Psychotherapy for Mexican Patients with Advanced Cancer
A cancer center in Mexico will test a culturally adapted therapy to help Mexican patients with advanced cancer find meaning, peace, and purpose at the end of life.
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High-specificity genome-scale cell-surface proteomics to find tumor targets
A cancer research project is trying to map all the proteins on the surface of ultra-rare sarcoma cells to find safe, targeted ways to treat them.
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Priorities for testing and choosing combination therapies in rhabdoid tumors to guide clinical trials
A coordinated, multi-site effort will rigorously test promising drug combinations in rhabdoid tumors to identify the most promising options for future patient trials.
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ecDNA in Cancer: Understanding and targeting circular DNA that drives tumor growth
A cancer-focused project to understand how extrachromosomal DNA helps tumors grow and resist treatment, and to develop new ways to target these mechanisms.
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Mobile phone imaging and AI to screen oral cancers in low-resource settings
A low-cost mobile phone device with artificial intelligence is being developed to help frontline health workers screen for oral cancer early in low-resource areas.
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Circulating metabolites as early warning signs for gastric cancer
Researchers will look at blood-based metabolites to find signs that predict gastric cancer risk in people, with a focus on those in large, multi-center cohorts.
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Affordable, handheld imaging for oral lesions in LMICs
A low-cost, handheld imaging device using RCM and OCT will help diagnose oral lesions in adults in Africa and Asia, reducing unnecessary biopsies.
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Pediatric Preclinical In Vivo Testing Center for Pediatric Sarcoma and Other Solid Tumors
A program uses mouse tumor models to identify promising drug candidates for children with sarcoma and other solid tumors.
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Center for Precision Theranostics at MSK Monmouth
A new center at MSK Monmouth will combine cancer imaging and therapy in one program to speed up the development and testing of targeted cancer treatments.
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Decoding how genetic signals shape T cells and fibroblasts in autoimmune inflammation
A research team is using advanced computer models and patient samples to understand how genetic differences influence how immune cells in joints behave in autoimmune arthritis.
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Genes and cell destiny: how our genome shapes early human development and cancer risk
A study using human stem cells and gene-editing to map how tiny genetic changes influence which cell types develop, with potential implications for cancer biology.
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Rewiring cancer signaling to improve colorectal cancer therapy
A cancer research project in colorectal cancer aims to test new ways to reprogram cancer cell signaling to make treatments work better.
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Leiomyosarcoma treatment insights from tumor genetics
A study looks at how tumor genetics relate to how leiomyosarcoma patients respond to standard systemic therapies.
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How mitochondrial Complex I truncations affect cancer cells
Learning how specific mitochondrial DNA mutations change cancer cell behavior in colorectal, kidney, and thyroid cancers.
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Predicting which flu strains vaccines should target
This work uses computer and biophysical models to forecast which flu virus strains are likely to spread so vaccines can better protect people.
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Access to Radioligand Therapy for Prostate Cancer in US Veterans
A study to understand how veterans with advanced prostate cancer access and experience radioligand therapy to guide better care.
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CAR T cells boosted to better attack solid tumors and resist PD-1 suppression
Engineered immune cells that target mesothelin and resist tumor suppression for people with solid tumors such as pleural mesothelioma.
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P-Selectin–Targeting Nanoparticles to Boost Immunotherapy in Fibrotic Cancers
Aims to use special nanoparticles that home in on aging cells in fibrotic tumors to make CAR T cell therapy and immune blockers work better for people with certain lung and liver cancers.
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How gene changes in breast cancer shape resistance to therapy
This research looks at how specific gene changes in breast cancer may cause tumors to become resistant to common therapies, with the goal of predicting and preventing resistance.
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Understanding how pancreatic cancer cells change state to resist treatment
Scientists are studying how pancreatic cancer cells switch between different states to resist drugs, with a focus on a state that tends to be linked to worse outcomes.
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ZBTB1’s role in aging blood cells and clonal blood disorders
A physician-researcher is studying how age-related changes in blood stem cells and a gene called ZBTB1 may give certain mutant clones in the blood a survival advantage, potentially leading to conditions like AML and MDS.
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Targeting ALT Cancer: Finding New Ways to control Alternative Lengthening of Telomeres
A researcher is studying why some cancers keep growing by using a mechanism called ALT and how to block it to help people with those cancers.
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Personalized radiation dose planning for nuclear medicine with MIRDsoft
This grant improves an open-source dosimetry tool to help doctors tailor radiation doses to individual patients.
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Hematopoietic stem cell–driven anti-tumor immunity in bladder cancer
This grant explores how a bladder cancer therapy called BCG helps the immune system fight cancer, with a focus on patient-specific immune responses.
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Enhancing Breast Cancer Trial Engagement with Digital Tools and Leadership
A physician-lead grant to speed breast cancer trials by using a smart digital platform to match patients with trials and improve trial operations.
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Modulating the tumor environment to improve nanoparticle delivery to cancer
A cancer-focused grant tests a method to make nanoparticles work better by altering the tumor surroundings to help medicines reach tumor cells.
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Origins and functions of pancreatic cancer–associated fibroblasts in pancreatic cancer
A research project studies how certain support cells in pancreatic cancer develop and influence tumor growth, with the aim of finding new treatment approaches.
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A targeted AR-directed therapy for advanced salivary gland cancer using darolutamide and leuprolide
A phase 2 trial tests whether combining a next-generation antiandrogen with hormone therapy helps people with advanced AR-positive salivary gland cancer.
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Intraperitoneal CAR T cells for peritoneal mesothelioma
A new approach uses CAR T cells delivered directly into the abdominal cavity to target mesothelioma, aiming to help people whose disease is confined to the abdomen.
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T Cell Precursors to Restore Immune Power After Stem Cell Transplants
This grant supports a patient-friendly approach to speed up immune recovery after a stem cell transplant by giving patients donor‑made T cell precursors that mature into healthy immune cells.
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Predicting which TCRs recognize cancer peptides using advanced AI models
A patient-focused grant that aims to improve how we predict which T cells recognize cancer-related peptides, using advanced AI to guide personalized immunotherapies.
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Drivers of early malignant change in diffuse gastric cancer
A research project aims to understand what triggers the transformation of stomach cells into cancer in people with diffuse gastric cancer, especially those with hereditary risk.
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Improve precision medicine for kidney cancer in people of African descent
A research project will explore why kidney cancer affects people of African ancestry differently and how to use genomics to guide better treatments.
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Digital activity tracking to understand metastatic breast cancer care
A smartphone-based activity tracking study will help people with metastatic cancer better understand how daily movement relates to health and treatment outcomes.
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Understanding how XPR1 controls brain phosphate and calcifications
Researchers are studying how a protein called XPR1 controls phosphate in brain cells to understand why calcium deposits form in the brain and how this relates to aging and neurological symptoms.
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Brief Meaning Centered Psychotherapy for Advanced Cancer Patients Receiving Homecare
A practical study tests a short, meaning-centered talk therapy delivered by home health nurses to reduce distress in people with advanced cancer who get home care.
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Expanding OncoKB: a scalable knowledgebase to guide precision cancer care
A NIH grant to grow OncoKB, a trusted database that helps doctors choose the right cancer treatments based on a patient’s tumor data.
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Breast cancer translational career program to build leaders
A grant funds a program to train physicians and scientists to lead translational breast cancer research and improve patient care.
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