Circulating metabolites as early warning signs for gastric cancer
Official title: Circulating metabolites as novel risk biomarkers for gastric cancer: a large multi-center prospective investigation
Funded at Sloan-Kettering Inst Can Research · NIH-11535363 · Data updated 2026-11-12
Researchers will look at blood-based metabolites to find signs that predict gastric cancer risk in people, with a focus on those in large, multi-center cohorts.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $89,491 |
| NIH project number | 3R37CA283041-03S1 |
| Project ID | NIH-11535363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults at risk for or interested in gastric cancer screening, particularly those with known H. pylori exposure or high-risk ethnic backgrounds.
✕Less likely to help
Individuals without identifiable risk factors or those not undergoing gastric cancer screening may see limited direct benefit.
What this research studies
This project analyzes metabolic profiles from blood samples collected over time to identify non-invasive biomarkers that predict future gastric cancer risk. By leveraging a large, multi-center prospective design, it aims to validate biomarkers that could be used in risk screening. The study builds on known risk factors like H. pylori infection but seeks additional predictors to improve risk stratification for diverse populations. The work could lead to simpler blood tests that help identify high-risk individuals before cancer develops.
Why it matters
Potential benefit: If successful, the research could enable earlier detection and targeted prevention of gastric cancer through non-invasive blood tests.
How similar studies have gone: Previous metabolomics studies have identified promising biomarkers, and this large prospective effort aims to validate and extend those findings.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Shu, Xiang — Sloan-Kettering Inst Can Research
- Study coordinator: Shu, Xiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.