Decoding how genetic signals shape T cells and fibroblasts in autoimmune inflammation
Official title: Deciphering the genomics of gene network regulation of T cell and fibroblast states in autoimmune inflammation
Funded at Sloan-Kettering Inst Can Research · NIH-11510129 · Data updated 2026-11-12
A research team is using advanced computer models and patient samples to understand how genetic differences influence how immune cells in joints behave in autoimmune arthritis.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 15, 2026 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,119,571 |
| NIH project number | 3U01HG012103-05S1 |
| Project ID | NIH-11510129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with rheumatoid arthritis who provide joint tissue samples or other clinical materials for research.
✕Less likely to help
Some participants may undergo sample collection without direct therapeutic benefit.
What this research studies
This project focuses on rheumatoid arthritis to map how genetic variations affect gene regulation in inflammatory T cells and fibroblast cells within joint tissue. It will build robust machine learning models to connect 3D genome interactions with cellular states that drive disease. By studying clinical samples and applying cutting-edge analytics, the team aims to reveal how different cell types interact to sustain inflammation in affected joints.
Why it matters
Potential benefit: If successful, the work could lead to clearer targets for therapies that modulate immune cell behavior in RA.
How similar studies have gone: Previous studies have shown that integrating genetic variation with cell-type-specific data can illuminate disease mechanisms, though full predictive models are still developing.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Leslie, Christina S — Sloan-Kettering Inst Can Research
- Study coordinator: Leslie, Christina S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.